Etoposide treatment suppresses atherosclerotic plaque development in cholesterol-fed rabbits.
Etoposide treatment suppresses atherosclerotic plaque development in cholesterol-fed rabbits.
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DOI：
10.1161/01.atv.12.11.1363
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发表时间：
1992-11
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影响因子：
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通讯作者：
M. de la Llera-Moya;G. Rothblat;J M Glick;J M England
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作者：
M. de la Llera-Moya;G. Rothblat;J M Glick;J M England
为了研究单核细胞/巨噬细胞和平滑肌细胞导致动脉粥样硬化病变的机制，我们研究了用依托泊苷治疗的胆固醇喂养兔子的动脉粥样硬化斑块形成，依托泊苷已被证明具有多种作用，可能干扰这两种细胞类型之间的相互作用（M.W. Aarnoudes 等，Virchows Arch B 1984;47:211-216 和 M. Rozencweig等人，癌症 1977；40：334-342）。我们的结果表明，对维持高胆固醇饮食的新西兰白兔进行长期依托泊苷治疗可减少主动脉内膜中脂肪条纹形成的程度。此外，与对照兔中的斑块相比，在依托泊苷存在下形成的斑块更薄，并且至少局部具有更少的纤维组织和更少的平滑肌细胞衍生的泡沫细胞。这些作用与饮食引起的高脂血症的程度或依托泊苷对血细胞计数的影响无关，并且可能与依托泊苷抑制内膜细胞增殖有关。
To study the mechanisms by which monocytes/macrophages and smooth muscle cells contribute to atherosclerotic lesions, we studied atherosclerotic plaque formation in cholesterol-fed rabbits treated with etoposide, a drug that has been shown to have several effects that could interfere with the proposed interactions between these two cell types (M.W. Aarnoudes et al, Virchows Arch B 1984;47:211-216 and M. Rozencweig et al, Cancer 1977;40:334-342). Our results show that long-term etoposide treatment of New Zealand White rabbits maintained on a high-cholesterol diet decreases the extent of fatty streak formation in the aortic intima. Moreover, the plaques formed in the presence of etoposide are thinner and at least focally have less fibrous tissue and fewer smooth muscle cell-derived foam cells than do plaques in control rabbits. These effects are independent of the extent of the diet-induced hyperlipemia or an effect of etoposide on blood cell count and may be related to the inhibition of intimal cell proliferation by etoposide.