Unusual frequencies of certain alternating purine‐pyrimidine runs in natural DNA sequences: relation to Z‐DNA
Unusual frequencies of certain alternating purine‐pyrimidine runs in natural DNA sequences: relation to Z‐DNA
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天然 DNA 序列中某些交替嘌呤-嘧啶的异常频率：与 Z-DNA 的关系
DOI：
10.1016/0014-5793(85)80769-9
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发表时间：
1985
期刊：
影响因子：
3.5
通讯作者：
T. Jovin
中科院分区：
文献类型：
--
作者：
E. Trifonov;A. Konopka;T. Jovin
对全长300000个核苷酸的原核生物、真核生物和线粒体DNA序列进行了分析，以找出嘌呤和嘧啶交替延伸的片段在出现、组成和碱基序列方面是否不寻常。与随机序列相比，长于5个核苷酸的交替序列在自然序列中的代表性明显不足。八核苷酸是最有缺陷的，其出现频率仅为随机序列预期频率的60%。出人意料的是，这些八聚体中有很高比例由具有重复结构(PuPyPuPy)2或(PyPuPu)2的交替四聚体组成。包含此类序列的DNA延伸可能形成对Sl核酸酶敏感的滑移(交错环)结构，该结构可能在B-到Z-DNA构象转换中作为局部未堆叠的中间产物。
Prokaryotic, eukaryotic and mitochondrial DNA sequences of total Length 300000 nucleotides have been analyzed to find out whether stretches of alternating purines and pyrimidines are unusual in terms of occurrence, composition and base sequence. Alternating runs longer than 5 nucleotides are significantly underrepresented in the natural sequences as compared to random ones. Octanucleotides are the most deficient, occurring at only 60% of the frequency expected in random sequences. An unexpectedly high proportion of these octamers consists of alternating tetramers with the repeat structure (PuPyPuPy)2or (PyPuPyPu)2. DNA stretches containing such sequences can potentially form a Sl nuclease sensitive slippage (staggered loop) structure, which might serve as a locally unstacked intermediate in the B- to Z-DNA conformational transition.
人类胎儿珠蛋白基因中的插入序列采用左手 Z 螺旋。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Kilpatrick,MW;Klysik,J;Singleton,CK;Zarling,DA;Jovin,TM;Hanau,LH;Erlanger,BF;Wells,RD
通讯作者：
Wells,RD
人类抗凝血酶 III 基因 5 端异常 DNA 长度多态性的表征。
影响因子：
14.9
作者：
Bock,SC;Levitan,DJ
通讯作者：
Levitan,DJ