A synaptic basis for memory storage in the cerebral cortex
A synaptic basis for memory storage in the cerebral cortex
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DOI：
10.1073/pnas.93.24.13453
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发表时间：
1996-11-26
影响因子：
11.1
通讯作者：
Bear, MF
中科院分区：
文献类型：
--
作者：
Bear, MF
大脑皮层神经元的一个基本特征是刺激选择性，而选择性的经验依赖变化是记忆形成的常见关联。我们用一个理论上的“学习规则”来解释神经元选择性的经验依赖性变化，来指导关于海马区和大脑皮层突触可塑性的基本机制的实验，这些实验表明，海马区和新大脑皮层中的许多突触是双向可修改的，这些修改持续的时间足够长，有助于长期记忆存储，控制突触可塑性迹象的关键变量是NMDA受体的激活量和皮质活动的近期历史。
A cardinal feature of neurons in the cerebral cortex is stimulus selectivity, and experience-dependent shifts in selectivity are a common correlate of memory formation. We have used a theoretical ''learning rule,'' devised to account for experience-dependent shifts in neuronal selectivity, to guide experiments on the elementary mechanisms of synaptic plasticity in hippocampus and neocortex, These experiments reveal that many synapses in hippocampus and neocortex are bidirectionally modifiable, that the modifications persist long enough to contribute to long-term memory storage, and that key variables governing the sign of synaptic plasticity are the amount of NMDA receptor activation and the recent history of cortical activity.