Surface modifications and molecular imprinting of polymers in medical and pharmaceutical applications
Surface modifications and molecular imprinting of polymers in medical and pharmaceutical applications
复制标题
DOI：
10.1016/s0168-3659(01)00259-0
复制
发表时间：
2001-05-14
影响因子：
10.8
通讯作者：
Peppas, NA
中科院分区：
文献类型：
--
作者：
Bures, P;Huang, YB;Peppas, NA
生物材料领域的最新发展是基于具有改进的表面和本体性质的聚合物的分子设计。通过添加系链进行表面改性的新技术可以使材料具有识别生物和药物化合物的能力。基于分子印迹的方法可以提高这种系统的识别能力。链拴系还可以通过允许药物在特定部位的靶向和定位来改善递送装置的粘膜粘附行为和药物的有效性。丙烯酸基水凝胶由于其柔韧性和非研磨性特征而非常适合于粘膜粘附，这减少了对接触组织的损伤引起的磨损。然而，这些装置的粘附和药物递送能力可以继续改进，因为目前已知的生物粘附材料被改进并且发现了更多的生物粘附材料。长PEG链在PAA水凝胶外壳上的束缚可以通过涉及亚硫酰氯的接枝反应，随后PEG接枝来实现。由于链与粘膜的锚定增强，随后的材料表现出粘膜粘附特性。理论计算可以优化Be系留结构。(C)2001年爱思唯尔科学BN。All rights reserved.
Recent developments in the field of biomaterials are based on molecular design of polymers with improved surface and bulk properties. Novel techniques of surface modification by addition of tethered chains can lead to materials with the ability to recognize biological and pharmaceutical compounds. Methods based on molecular imprinting can increase the recognition capabilities of such systems. Chain tethering can also can improve the mucoadhesive behavior of a delivery device and the effectiveness of a drug by allowing targeting and localization of a drug at a specific site. Acrylic-based hydrogels are well-suited for mucoadhesion due to their flexibility and nonabrasive characteristics which reduce damage-causing attrition to the tissues in contact. However, the adhesive and drug delivery capabilities of these devices can continue to be improved as presently known bioadhesive materials are modified and more bioadhesive materials are discovered. Tethering of long PEG chains on PAA hydrogels rind their copolymers can be achieved by grafting reactions involving thionyl chloride, followed by PEG grafting. The ensuing materials exhibit mucoadhesive properties due to enhanced anchoring of the chains with the mucosa. Theoretical calculations can lead to optimization of Be tethered structure. (C) 2001 Elsevier Science BN. All rights reserved.