Medial versus lateral prefrontal dissociation in movement selection and inhibitory control
Medial versus lateral prefrontal dissociation in movement selection and inhibitory control
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DOI：
10.1016/j.brainres.2006.11.017
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发表时间：
2007-02-09
期刊：
影响因子：
2.9
通讯作者：
Paans, A. M. J.
中科院分区：
文献类型：
--
作者：
de Jong, B. M.;Paans, A. M. J.
我们的目的是验证这样一个假设，即大脑对运动的选择包括主动抑制不想要的运动。为此，采用了大脑激活范式，将食指屈曲和类似的运动与手指3、4、5一起进行比较。通过正电子发射断层扫描(PET)测量10名健康受试者在两种运动任务和休息时的脑血流灌注，评估了大脑激活情况。统计参数图(SPM)显示，在较少活动的情况下(即单独的食指屈曲与全手屈曲相比)，(前)前额内侧活动显著增加，苍白球和丘脑也有轻微的变化。这些增加表明了一种通过主动抑制不想要的运动而调节的选择机制。所有运动反应的抑制都是从与休息相关的前额叶前外侧激活(只有听觉提示)推断出来的，与两种运动条件形成对比。这种抑制功能的分离规定了反应选择和抑制控制的互补特征，在这种方式下，向内侧前额叶表面，从一般抑制到日益选择性的抑制的转变允许动作的内部秩序。(C)2006爱思唯尔B.V.保留所有权利。
We aimed to test the hypothesis that the cerebral selection of movement includes active suppression of unwanted movements. To that end, a cerebral activation paradigm was used in which index finger flexion was compared with similar movement, made together with fingers 3, 4, 5. Cerebral activations were assessed by positron emission tomography (PET) measurements of cerebral perfusion in 10 healthy subjects, during the two motor tasks and rest. Statistical parametric mapping (SPM) revealed significant increase of (antero)medial prefrontal activity and subtle changes in pallidum and thalamus in the condition of less movement, i.e. isolated index finger flexion contrasted to full-hand flexion. These increases indicated a mechanism of selection mediated by active suppression of unwanted movements. Suppression of all motor responses was inferred from anterolateral prefrontal activation related to rest (with only auditory cues), contrasted to both motor conditions. This segregation of inhibitory functions specifies the complementary character of response selection and inhibitory control, in such a way, that towards the medial prefrontal surface, a transition from general to increasingly selective inhibition allows the internal ordering of action. (c) 2006 Elsevier B.V. All rights reserved.