Fine mapping and subphenotyping implicates ADRA1B gene variants in psoriasis susceptibility in a Chinese population
Fine mapping and subphenotyping implicates ADRA1B gene variants in psoriasis susceptibility in a Chinese population
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精细定位和亚表型分析表明 ADRA1B 基因变异与中国人群银屑病易感性有关
DOI：
10.2217/epi-2018-0131
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发表时间：
2019-03-01
期刊：
影响因子：
3.8
通讯作者：
Schork, Nicholas J.
中科院分区：
文献类型：
--
作者：
Fan, Xing;Wang, Hongyan;Schork, Nicholas J.
目的：5q33.3上的一个基因组区域位于白细胞介素128（IL128）和垂体肿瘤转化基因1（PTTG1）基因之间并包含这两个基因，且包含许多潜在的银屑病致病变异体。我们旨在进一步研究该区域内及其周围变异体的影响。
材料与方法：我们使用基于最小绝对收缩和选择算子（LASSO）的回归分析来评估2171个变异体对银屑病易感性的独立贡献，并测试它们与不同临床银屑病亚型的关联。
结果：我们发现α1B -肾上腺素能受体（ADRA1B）基因变异体在中国人群中与银屑病有关。与白细胞介素 - 128（IL - 128）和垂体肿瘤转化基因1（PTTG1）变异体相比，ADRA1B基因变异体与中重度疾病组的关联性更强，且银屑病发病年龄更早。
结论：ADRA1B基因变异体与银屑病的关联可以解释为什么白细胞介素 - 12B（IL - 12B）、ADRA1B和PTTG1基因区域的变异体与银屑病相关。
Aim: A genomic region on 5q33.3 lies between and encompasses the IL128 and PTTG1 genes, and contains many potential psoriasis causal variants. We aimed to further examine the influence of variants in and around this region. Materials & methods: We used least absolute shrinkage and selection operator (LASSO)-based regression analysis to assess independent contributions of 2171 variants to psoriasis susceptibility and tested them for association with different clinical psoriasis subtypes. Results: We found that ADRA1B gene variants contribute to psoriasis in Chinese population. ADRA1B gene variants have a stronger association with moderate-to-severe disease group and an earlier age at onset of psoriasis than IL-128 and PTTG1 variants. Conclusion: The association of variants in the ADRA1B gene with psoriasis could explain why variants in the IL-12B, ADRA1B and PTTG1 gene regions are associated with psoriasis.