Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice
Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice
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DOI：
10.1016/j.fitote.2011.07.011
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发表时间：
2011-10-01
期刊：
影响因子：
3.4
通讯作者：
Du, Jun-Rong
中科院分区：
文献类型：
--
作者：
Cheng, Li-Ling;Chen, Xi-Nan;Du, Jun-Rong
我们研究了z -藁本内酯（LIG）对东莨菪碱诱导的ICR小鼠记忆损伤的影响。口服LIG （2.5 ~ 40 mg/kg）或他克林（10 mg/kg） 26 d。观察东莨菪碱（2 mg/kg, ig）给药后Morris水迷宫和y迷宫的行为。用分光光度法测定中央乙酰胆碱酯酶（AChE）和胆碱乙酰转移酶（ChAT）活性。LIG显著改善空间长期记忆和短期记忆障碍，抑制AChE活性，增加ChAT活性。此外。LIG和他克林在神经行为和胆碱能评价方面的疗效相当。这些数据表明，LIG可能通过增强胆碱能功能来缓解记忆缺陷。(C) 2011 Elsevier B.V.版权所有
We investigated the effect of Z-ligustilide (LIG) on scopolamine-induced memory impairment in ICR mice. LIG (2.5-40 mg/kg) or tacrine (10 mg/kg) was orally administrated for 26 days. Behavior was examined in the Morris water maze and Y-maze after scopolamine administration (2 mg/kg, i.p.). The central acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) activities were assessed spectrophotometrically. LIG significantly improved spatial long-term memory and short-term memory impairment, inhibited AChE activity and increased ChAT activity. Moreover. LIG and tacrine showed the comparable efficacy in both neurobehavioral and cholinergic evaluation. These data suggest that LIG may alleviate memory deficits probably via enhancing cholinergic function. (C) 2011 Elsevier B.V. All rights reserved.