The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats
The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats
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DOI：
10.1016/j.peptides.2004.05.007
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发表时间：
2004-08-01
期刊：
影响因子：
3
通讯作者：
Oiso, Y
中科院分区：
文献类型：
--
作者：
Banno, R;Arima, H;Oiso, Y
观察了外周注射黑素皮质素激动剂黑素皮质素II(MTII)对大冢Long-Evans Tokushima Fatty(OLETF)大鼠胰岛素敏感性和糖耐量的影响。皮下注射MTII和渗透压微型泵可减少OLETF大鼠的摄食量和体重。在第9天的胰岛素耐量试验中，MTII组的胰岛素敏感性明显高于自由进食组和配对进食组。在第11天和第23天的糖耐量试验中，MTII组的血糖值也显著低于自由进食组。因此，MTII增加了OLETF大鼠的胰岛素敏感性并改善了糖耐量。(C)2004 Elsevier Inc.保留所有权利。
Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats. (C) 2004 Elsevier Inc. All rights reserved.