American Society of Biomechanics Journal of Biomechanics Award 2013: cortical bone tissue mechanical quality and biological mechanisms possibly underlying atypical fractures.
American Society of Biomechanics Journal of Biomechanics Award 2013: cortical bone tissue mechanical quality and biological mechanisms possibly underlying atypical fractures.
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DOI：
10.1016/j.jbiomech.2015.01.032
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发表时间：
2015-04-13
影响因子：
2.4
通讯作者：
Fritton, J. Christopher
中科院分区：
文献类型：
--
作者：
Geissler, Joseph R.;Bajaj, Devendra;Fritton, J. Christopher
生物力学文献包含了许多在治疗计划中具有重要作用的典型骨折类型背后的众所周知的机制。最近出现的“非典型”骨折与长期使用预防骨质疏松症的药物有关，重新引起了人们对药物对骨组织水平质量的影响的兴趣。虽然这种类型的骨折在引入抗吸收双膦酸类药物之前就被认识到了，最近被比作应力性骨折，但导致非典型骨折的机制(S)尚未明确确定。因此，这些药物与不典型骨折之间的因果关系尚未确定。医生、生物工程师和其他对骨骼生物力学感兴趣的人正在努力改进骨折预防诊断，并设计治疗方法，以避免未来出现这种严重的副作用。这篇综述考察了骨组织损伤背后的机制，这种损伤可能会导致长期使用双膦酸类药物越来越多地观察到的非典型骨折模式。我们和其他人的最新发现支持了正常、健康的挖掘和隧道填充背后的机制，即皮质组织内的骨重塑单元加强了机械完整性。长期服用双膦酸类药物可减少骨组织的改建和延长组织的老化，从而改变骨皮质抵抗周期性载荷损伤的能力。对这种潜在骨折的评估的发展将恢复人们对药物治疗的信心，这些药物治疗有可能使我们老龄化人口中的数百万人免于经常因骨折而导致的发病率和死亡。
The biomechanics literature contains many well-understood mechanisms behind typical fracture types that have important roles in treatment planning. The recent association of “atypical” fractures with long-term use of drugs designed to prevent osteoporosis has renewed interest in the effects of agents on bone tissue-level quality. While this class of fracture was recognized prior to the introduction of the anti-resorptive bisphosphonate drugs and recently likened to stress fractures, the mechanism(s) that lead to atypical fractures have not been definitively identified. Thus, a causal relationship between these drugs and atypical fracture has not been established. Physicians, bioengineers and others interested in the biomechanics of bone are working to improve fracture-prevention diagnostics, and the design of treatments to avoid this serious side-effect in the future. This review examines the mechanisms behind the bone tissue damage that may produce the atypical fracture pattern observed increasingly with long-term bisphosphonate use. Our recent findings and those of others reviewed support that the mechanisms behind normal, healthy excavation and tunnel filling by bone remodeling units within cortical tissue strengthen mechanical integrity. The ability of cortical bone to resist the damage induced during cyclic loading may be altered by the reduced remodeling and increased tissue age resulting from long-term bisphosphonate treatment. Development of assessments for such potential fractures would restore confidence in pharmaceutical treatments that have the potential to spare millions in our aging population from the morbidity and death that often follow bone fracture.
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影响因子：
4.1
作者：
Bellido, Teresita;Plotkin, Lilian I.
通讯作者：
Plotkin, Lilian I.
影响因子：
4
作者：
Ang, B. F. H.;Koh, J. S. B.;Howe, T. S.
通讯作者：
Howe, T. S.
影响因子：
2.4
作者：
BURR, DB;SCHAFFLER, MB;FREDERICKSON, RG
通讯作者：
FREDERICKSON, RG
影响因子：
6.2
作者：
Beck, TJ;Oreskovic, TL;Cummings, SR
通讯作者：
Cummings, SR
影响因子：
4.2
作者：
Allen, Matthew R.;Reinwald, Susan;Burr, David B.
通讯作者：
Burr, David B.