Age-related changes in the avian primary lymphoid organs (thymus and bursa of Fabricius)
Age-related changes in the avian primary lymphoid organs (thymus and bursa of Fabricius)
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DOI：
10.1002/jemt.10416
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发表时间：
2003-12-15
影响因子：
2.5
通讯作者：
Laurà, R
中科院分区：
文献类型：
--
作者：
Ciriaco, E;Píñera, PP;Laurà, R
禽类的初级淋巴器官，胸腺和法氏囊，在某些情况下会发生年龄相关的变化，导致器官的完全萎缩。然而，进化过程的时间表以及器官结构和功能的后果在时间框架和物种之间的结构变化方面存在很大差异。另一方面，与大量文献报道哺乳动物初级淋巴器官的结构和功能变化不同，鸟类胸腺和法氏囊的年龄相关性变化是罕见的、零散的和异质性的。本文回顾了目前关于这一主题的文献，主要集中在法氏囊的内陷。(C)2003年Wiley-Liss，Inc.
The avian primary lymphoid organs, the thymus and the bursa of Fabricius, undergo age-dependent changes leading in some cases to the complete atrophy of the organ. Nevertheless, the timetable of the involutive process as well as the consequences in the structure and functionality of the organs vary largely in the time frame and structural changes among species. On the other hand, and in contrast with the large body of literature reporting the structural and functional changes in mammalian primary lymphoid organs, the age-dependent changes in avian thymus and bursa of Fabricius are scarce, fragmentary, and heterogeneous. This article reviews the current literature on this topic, and focuses primarily on the involution of the bursa of Fabricius. (C) 2003 Wiley-Liss, Inc.