Temporal discrimination learning in severe amnesic patients reveals an alteration in the timing of eyeblink conditioned responses
Temporal discrimination learning in severe amnesic patients reveals an alteration in the timing of eyeblink conditioned responses
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DOI：
10.1037/0735-7044.113.1.10
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发表时间：
1999-02-01
影响因子：
1.9
通讯作者：
Disterhoft, JF
中科院分区：
文献类型：
--
作者：
McGlinchey-Berroth, R;Brawn, C;Disterhoft, JF
本研究探讨了海马系统是否在眨眼经典条件反射中对条件反应时间的调节作用。7例双颞叶遗忘症患者和7例对照者被随机呈现2个音调条件刺激（CS），分别与两个不同的刺激间隔（ISI）在延迟条件反射任务配对。结果发现，在较长的ISI下，遗忘症患者的CR发生显著早于对照组参与者的CR。痴呆患者也产生了显着更多的非适应性CR比对照组的参与者，他们的收购水平低于对照组参与者等同ISI后，他们没有表现出灭绝与较长的ISI。这些数据表明，海马系统的作用，在控制条件眨眼反应的精确定时，并在获取和熄灭的时间歧视任务的背景下的反应。
This study investigated whether the hippocampal system plays a modulatory role in the timing of conditioned responses (CRs) in eyeblink classical conditioning. Seven bitemporal amnesic patients and 7 controls were randomly presented 2 tone conditioned stimuli (CSs) that were individually paired with two different interstimulus intervals (ISIs) in a delay conditioning task. It was found that amnesic patients' CRs occurred significantly earlier than control participants' CRs at the longer ISI. Amnesic patients also produced significantly more nonadaptive CRs than did control participants, their level of acquisition was less than that of control participants after equating for ISI, and they did not show extinction with the longer ISI. These data suggest a role of the hippocampal system in controlling the precise timing of conditioned eyeblink responses and in acquiring and extinguishing responses within the context of a temporal discrimination task.