The effects of antipyretics on influenza virus encephalitis in mice and chicks.
The effects of antipyretics on influenza virus encephalitis in mice and chicks.
复制标题
DOI：
10.1292/jvms.65.1185
复制
发表时间：
2003-11
期刊：
影响因子：
--
通讯作者：
Y. Sunden;C. Park;K. Matsuda;Akiko Anagawa;Takashi Kimura;K. Ochiai;H. Kida;T. Umemura
中科院分区：
文献类型：
--
作者：
Y. Sunden;C. Park;K. Matsuda;Akiko Anagawa;Takashi Kimura;K. Ochiai;H. Kida;T. Umemura
为了研究解热药对小鼠和家禽流行性乙型脑炎模型的影响，我们注射了大量的解热药，乙酰水杨酸(阿司匹林)和双氯芬酸钠(伏他连)。退热治疗对小鼠脑炎模型的组织学和免疫组织化学均无明显影响。而雏鸡仅在退热剂治疗组出现以血管周围袖套和胶质细胞为主的中枢神经系统损伤，伏他林组病毒抗原主要分布在神经胶质细胞或血管内皮细胞的核中。我们在这里证明，退热治疗加剧了流感病毒在雏鸡中的血源性传播到中枢神经系统，但不影响小鼠的跨神经感染。
To investigate the effect of antipyretics on the murine and poultry models of influenzal encephalitis, we injected large quantities of antipyretics, acetylsalicylic acid (aspirin) and dicrofenac sodium (voltaren). The effect of antipyretic treatment on the murine encephalitis model was unremarkable histologically and immunohistochemically. Whereas in chicks, CNS lesions consisting of perivascular cuffing and gliosis appeared only in those animals treated with the antipyretics and viral antigen was detected mainly in the nuclei of glial cells or vascular endothelia of voltaren-treated animals. We here demonstrate that antipyretic treatment aggravated the hematogenous spread of the influenza virus to the CNS in chicks, but did not affect the transneural infection in mice.