Volatile oil composition and antiproliferative activity of Laurus nobilis, Origanum syriacum, Origanum vulgare, and Salvia triloba against human breast adenocarcinoma cells
Volatile oil composition and antiproliferative activity of Laurus nobilis, Origanum syriacum, Origanum vulgare, and Salvia triloba against human breast adenocarcinoma cells
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DOI：
10.1016/j.nutres.2010.04.001
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发表时间：
2010-04-01
影响因子：
4.5
通讯作者：
Afifi, Fatma U.
中科院分区：
文献类型：
--
作者：
Al-Kalaldeh, Jelnar Z.;Abu-Dahab, Rana;Afifi, Fatma U.
药用植物和烹饪草药在过去十年中作为细胞毒性和抗肿瘤剂获得了重要性。我们假设，一些常用的香料与报道的抗菌活性可能具有抗增殖活性。在本研究中，选定的香料在约旦使用的化学分析和研究其抗增殖活性的乳腺癌细胞系（MCF 7）。采用气相色谱-质谱联用技术分析了月桂、牛至、牛至和三叶鼠尾草的挥发油成分。采用磺基罗丹明B法评价水提挥发油、粗提醇提物和粗提水提物的抗增殖活性。1，8-桉叶醇是金鱼草和三叶草加氢蒸馏油的主要成分，含量分别为40.91%和45.16%。丁香的主要成分是香芹酚（47.10%），而丁香的主要成分是水合桧烯（27.19%）。丁香、百合和三叶草的乙醇粗提物显示出对MCF 7的抗增殖活性，IC 50值分别为6.40、24.49和25.25 μ g/mL。然而，没有一个被测试的植物物种的水蒸馏精油或其水提取物表现出细胞毒性活性。(C)2010年爱思唯尔公司All rights reserved.
Medicinal plants and culinary herbs have gained importance in the last decade as cytotoxic and antitumor agents. We hypothesized that some of the commonly used spices with reported antimicrobial activity might have antiproliferative activity. In the present study, selected spices used in Jordan were chemically analyzed and investigated for their antiproliferative activity to the adenocarcinoma of breast cell line (MCF7). The composition of the essential oils of Laurus nobilis L, Origanum syriacum L, Origanum vulgare L, and Salvia triloba L was analyzed by gas chromatography-mass spectrometry. The antiproliferative activities of the hydrodistilled volatile oils and the crude ethanol and water extracts were evaluated using the sulphorhodamine B assay. 1,8-Cineol was the major constituent in the hydrodistilled oils of both plants, L nobilis and S triloba, with concentrations of 40.91% and 45.16%, respectively. The major constituent of 0 syriacum was the carvacrol (47.10%), whereas that of 0 vulgare was trans-sabinene hydrate (27.19%). The ethanol crude extracts of 0 syriacum, L nobilis, and S triloba showed antiproliferative activity to MCF7 with IC50 values 6.40, 24.49, and 25.25 mu g/mL, respectively. However, none of the hydrodistilled essential oils of the tested plant species or their aqueous extracts demonstrated cytotoxic activity. (C) 2010 Elsevier Inc. All rights reserved.