NEUROBEHAVIORAL EVALUATION OF VENEZUELAN WORKERS EXPOSED TO ORGANIC-SOLVENT MIXTURES
NEUROBEHAVIORAL EVALUATION OF VENEZUELAN WORKERS EXPOSED TO ORGANIC-SOLVENT MIXTURES
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DOI：
10.1002/ajim.4700270103
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发表时间：
1995-01-01
影响因子：
3.5
通讯作者：
MAIZLISH, N
中科院分区：
文献类型：
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作者：
ESCALONA, E;YANES, L;MAIZLISH, N
为了评估世界卫生组织（WHO）神经行为核心测试组合（NCTB）的适用性，我们评估了53名男性和29名女性委内瑞拉工人暴露于粘合剂工厂的有机溶剂混合物，以及56名男性和11名女性工人未暴露于任何类型的神经毒性化学品。未暴露工人的平均年龄为30岁，暴露工人的平均年龄为33岁，两组工人的平均受教育年限均为8年，平均暴露时间为7年。NCTB评估中枢神经系统功能，由七项测试组成，测量简单运动功能，短期记忆，眼手协调，情感行为，心理感知和速度。电池包括：情绪状态（POMS）曲线;注意力和反应速度的简单反应时间;数字广度远听觉记忆;圣安娜手灵巧度;感知运动速度的数字符号;视觉感知和记忆的本顿视觉保持;以及运动稳定性的追求瞄准II。在13个子测试中，暴露组的表现比非暴露组差。平均表现的差异范围在5%和89%之间，特别是在POMS（紧张-焦虑，愤怒-敌意，抑郁-拒绝，疲劳-惰性，困惑-困惑），简单反应时间，数字符号和圣安娜钉板（p <0.05）。在多变量回归分析中，控制年龄、性别和教育的影响，暴露者在POMS中的紧张焦虑、敌对、抑郁和混乱情绪以及数字符号和简单反应时的表现明显较差（p <0.05）。在协方差分析中，使用暴露年数，这些变化也与剂量相关。与未暴露者相比，暴露受试者表现出疲劳、记忆困难、意识模糊、上下肢感觉异常和睡眠障碍等主观症状的频率增加。我们的结论是，该方法适用于研究的人口。受试者接受了NCTB的测试，并进行了令人满意的管理，除了偶尔的困难，在口头理解的POMS，这是唯一的测试，需要更苛刻的口头技能的子测试。行为缺陷的程度与可能的高暴露水平和以前报告的长期溶剂暴露工人的缺陷范围一致。(C)1995 Wiley-Liss，Inc.
To assess the applicability of the World Health Organization (WHO) Neurobehavioral Core Test Battery (NCTB), we evaluated 53 male and 29 female Venezuelan workers exposed to mixtures of organic solvents in an adhesive factory, and 56 male and 11 female workers unexposed to any type of neurotoxic chemical. The average age of unexposed workers was 30 years and 33 years for those exposed, average schooling for both groups was 8 years, and the mean duration of exposure was 7 years. The NCTB, which assesses central nervous system functions, is composed of seven tests that measure simple motor function, short-term memory, eye-hand coordination, affective behavior, and psychomotor perception and speed. The battery includes: profile of mood states (POMS); Simple Reaction Time for attention and response speed; Digit Span far auditory memory; Santa Ana manual dexterity; Digit-Symbol for perceptual motor speed; the Benton visual retention for visual perception and memory; and Pursuit Aiming II for motor steadiness. In each of 13 subtests, the exposed group had a poorer performance than the nonexposed group. The range of differences in mean performance was between 5% and 89%, particularly in POMS (tension-anxiety, anger-hostility, depression-rejection, fatigue-inertia, confusion-bewilderment), Simple Reaction Time, Digit-Symbol, and Santa Ana Pegboard (p < .05). In multivariate regression analyses, controlling for the effects of age, sex, and education, significantly poorer performance in the exposed was found for tension-anxiety, hostility, depression, and confusion moods in the POMS, and in digit-symbol and simple reaction time (p < .05). These alterations were also dose-related using years of exposure in analyses of covariance. Compared to the nonexposed, the exposed subjects demonstrated an increased frequency of subjective symptoms of fatigue, difficulties with memory, confusion, paresthesias in upper and lower extremities, and sleep disturbances. We conclude that the methodology is applicable to the population studied. The tests of the NCTB were accepted by the subjects and were administered satisfactorily, except for occasional difficulties in verbal comprehension in subtests of POMS, which is the only test that requires more demanding verbal skills. The magnitude of the behavioral deficits is consistent with the probable high level of exposure and with the range of deficits previously reported in workers with long-term solvent exposures. (C) 1995 Wiley-Liss, Inc.