A model of ultrasound-enhanced diffusion in a biofilm
A model of ultrasound-enhanced diffusion in a biofilm
复制标题
DOI：
10.1121/1.4954635
复制
发表时间：
2016-06-01
影响因子：
2.4
通讯作者：
Marshall, Jeffrey S.
中科院分区：
文献类型：
--
作者：
Marshall, Jeffrey S.
提出了一个纳米颗粒在生物膜中传输的随机模型，解释了声学振荡和由于与生物膜孔壁相互作用而导致的间歇性滞留如何导致扩散增强。推导了有效扩散系数随振速幅值的平方变化的表达式。通过将解析扩散解与随机模型预测进行比较，验证了该表达式的正确性。随机模型被应用于一个与脂质体渗透到水凝胶中有关的例子问题，它被发现得到了脂质体浓度随进入生物膜的距离呈指数变化的解。(C)2016美国声学学会
A stochastic model is presented for nanoparticle transport in a biofilm to explain how the combination of acoustic oscillations and intermittent retention due to interaction with the pore walls of the biofilm leads to diffusion enhancement. An expression for the effective diffusion coefficient was derived that varies with the square of the oscillation velocity amplitude. This expression was validated by comparison of an analytical diffusion solution to the stochastic model prediction. The stochastic model was applied to an example problem associated with liposome penetration into a hydrogel, and it was found to yield solutions in which liposome concentration varied exponentially with distance into the biofilm. (C) 2016 Acoustical Society of America