Ferulic acid and its water-soluble derivatives inhibit nitric oxide production and inducible nitric oxide synthase expression in rat primary astrocytes
Ferulic acid and its water-soluble derivatives inhibit nitric oxide production and inducible nitric oxide synthase expression in rat primary astrocytes
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阿魏酸及其水溶性衍生物抑制大鼠原代星形胶质细胞中一氧化氮的产生和诱导型一氧化氮合酶的表达
DOI：
10.1080/09168451.2017.1336925
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Sakamoto T
中科院分区：
文献类型：
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作者：
Kikugawa M;Ida T;Ihara H;Sakamoto T
我们最近报道了本课题组先前开发的两种水溶性阿魏酸衍生物（1-阿魏酰甘油、1-阿魏酰双甘油）在体外和体内对β淀粉样蛋白诱导的神经变性具有保护作用。在目前的研究中，我们的目的是通过检查衍生物抑制星形胶质细胞异常激活的能力来进一步了解这一过程，星形胶质细胞是神经变性的关键事件。我们研究了阿魏酸（FA）衍生物对大鼠原代星形胶质细胞一氧化氮（NO）生成和诱导型一氧化氮合酶（iNOS）表达的影响。结果表明，这些化合物以浓度依赖性方式抑制NO产生和iNOS表达，这些作用的机制是抑制核因子-κB途径。这一证据表明，FA及其衍生物可能是有效的神经保护剂，并可用于治疗神经退行性疾病，如阿尔茨海默病和帕金森病。
We recently reported that two water-soluble derivatives of ferulic acid (1-feruloyl glycerol, 1-feruloyl diglycerol) previously developed by our group exhibited protective effects against amyloid-β–induced neurodegenerationin vitroandin vivo. In the current study, we aimed to further understand this process by examining the derivatives’ ability to suppress abnormal activation of astrocytes, the key event of neurodegeneration. We investigated the effects of ferulic acid (FA) derivatives on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in rat primary astrocytes. The results showed that these compounds inhibited NO production and iNOS expression in a concentration-dependent manner and that the mechanism underlying these effects was the suppression of the nuclear factor-κB pathway. This evidence suggests that FA and its derivatives may be effective neuroprotective agents and could be useful in the treatment of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease.