Measuring blood pressure in mice using volume pressure recording, a tail-cuff method.
Measuring blood pressure in mice using volume pressure recording, a tail-cuff method.
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DOI：
10.3791/1291
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发表时间：
2009-05-15
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影响因子：
--
通讯作者：
Balakrishnan, Anju
中科院分区：
文献类型：
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作者：
Daugherty, Alan;Rateri, Debra;Balakrishnan, Anju
CODA 8通道高重复性无创血压系统可同时测量多达8只小鼠或大鼠的血压。CODA尾袖带系统使用容积压力记录（VPR）通过确定尾血容量来测量血压。一个专门设计的压差传感器和一个闭塞尾袖测量总血量在尾部，而不需要获得个人的脉搏信号。特别注意闭塞袖带的长度，以获得最准确的血压读数。VPR可以很容易地获得深色皮肤啮齿动物的读数，如C57 BL 6小鼠，并且与MRI兼容。CODA系统为您提供六（6）种不同血压参数的测量值;收缩压和舒张压、心率、平均血压、尾血流量和尾血容量。可以在清醒或麻醉的小鼠或大鼠上进行测量。CODA系统包括控制器、笔记本电脑、软件、袖带、动物固定器、红外线加温垫和红外线温度计。有七种不同的保持器尺寸，适用于小至8克的小鼠，大至900克的大鼠。
The CODA 8-Channel High Throughput Non-Invasive Blood Pressure system measures the blood pressure in up to 8 mice or rats simultaneously. The CODA tail-cuff system uses Volume Pressure Recording (VPR) to measure the blood pressure by determining the tail blood volume. A specially designed differential pressure transducer and an occlusion tail-cuff measure the total blood volume in the tail without the need to obtain the individual pulse signal. Special attention is afforded to the length of the occlusion cuff in order to derive the most accurate blood pressure readings. VPR can easily obtain readings on dark-skinned rodents, such as C57BL6 mice and is MRI compatible. The CODA system provides you with measurements of six (6) different blood pressure parameters; systolic and diastolic blood pressure, heart rate, mean blood pressure, tail blood flow, and tail blood volume. Measurements can be made on either awake or anesthetized mice or rats. The CODA system includes a controller, laptop computer, software, cuffs, animal holders, infrared warming pads, and an infrared thermometer. There are seven different holder sizes for mice as small as 8 grams to rats as large as 900 grams.