Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program
Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program
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DOI：
10.1016/j.ajog.2009.05.052
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发表时间：
2009-09-01
影响因子：
9.8
通讯作者：
Baxter, Jason K.
中科院分区：
文献类型：
--
作者：
Almario, Christopher V.;Seligman, Neil S.;Baxter, Jason K.
目的：先前的研究指出，接受美沙酮治疗的阿片类药物成瘾妇女的早产率 (PTB) 较高。我们试图确定这一人群中发生 PTB 的危险因素。研究设计：我们对 2000 年至 2006 年间接受美沙酮治疗的阿片类药物成瘾孕妇进行了一项回顾性队列研究，这些妇女产下一个新生儿。评估为 37 周以内 PTB 潜在风险因素的变量包括医疗和感染合并症和“美沙酮补充剂”（违禁药物和/或酒精）。 结果：总体 PTB 率为 29±1% (75/258)。没有医学或感染性合并症可预测 PTB 在除美沙酮外滥用 0、1、2 或 3 种或更多补充剂的女性中，PTB 发生率分别为 24±2%（参考值）、25±5%（P=50）、47.6%（P=.04）和 64±7%（P=.01）结论：服用美沙酮的女性的 PTB 发生率(29.1%) 几乎是全国平均水平 (11·1%) 的 3 倍，滥用 2 种或更多美沙酮补充剂的人患 PTB 的风险进一步增加
OBJECTIVE: Prior studies noted elevated preterm birth (PTB) rates among opiate-addicted women treated with methadone We sought to determine the risk factors for PTB in this population.STUDY DESIGN: We performed a retrospective cohort study of opiate-addicted gravid women treated with methadone who delivered a single neonate between 2000 and 2006 Variables evaluated as potential risk factors for PTB less than 37 weeks included medical and infectious comorbidities and "supplements to methadone" (illicit drugs and/or alcohol).RESULTS: The overall PTB rate was 29 1% (75/258). No medical or infectious comorbidity was predictive of PTB Among women abusing 0, 1. 2, or 3 or more supplements in addition to methadone, the PTB rate was 24 2% (reference), 25 5% (P = 50), 47.6% (P=.04), and 64 7% (P=.01), respectivelyCONCLUSION: The PTB rate among women on methadone (29.1%) is nearly 3 times the national average (11 1%), and those abusing 2 or more supplements to methadone are at further increased risk for PTB