Sickle Cell Anemia and Babesia Infection.
Sickle Cell Anemia and Babesia Infection.
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DOI：
10.3390/pathogens10111435
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发表时间：
2021-11-04
期刊：
影响因子：
--
通讯作者：
Lobo CA
中科院分区：
文献类型：
--
作者：
Beri D;Singh M;Rodriguez M;Yazdanbakhsh K;Lobo CA
巴贝虫是一种红细胞内专性顶复门寄生虫，在上个世纪，其通过人畜共患病与人类感染有关，现在广泛传播，特别是在美国和欧洲的部分地区。它是通过蜱虫叮咬自然传播的，但从受感染的献血者那里输血也被证明是传播的主要来源。当被感染时，大多数人在临床上没有症状，但当寄生虫感染免疫功能低下的个体时，它可以被证明是致命的。溶血和贫血是伴随许多传染病的两种常见症状，尤其是针对红细胞的寄生虫病。在临床上，这对于易于发生溶血并依赖频繁输血的受试者（如镰状细胞性贫血或地中海贫血患者）来说是一个严重的问题。关于巴氏疟原虫在这些血红蛋白病中的发病机制知之甚少，大多数相似之处来自其进化上相关的疟原虫寄生虫，其在人类宿主中具有相同的环境生态位，即红细胞。在体外以及在体内巴贝虫感染的小鼠镰状细胞病（SCD）模型支持抑制红细胞内寄生虫增殖，但驱动这种血红蛋白病对感染的保护机制尚未得到充分研究。本文综述了我们目前对巴贝斯虫感染和血红蛋白病的认识，重点介绍了这种寄生虫耐药性背后的可能机制以及巴贝斯虫感染的人类宿主在其珠蛋白基因中携带突变所面临的临床影响。
Babesia is an intraerythrocytic, obligate Apicomplexan parasite that has, in the last century, been implicated in human infections via zoonosis and is now widespread, especially in parts of the USA and Europe. It is naturally transmitted by the bite of a tick, but transfused blood from infected donors has also proven to be a major source of transmission. When infected, most humans are clinically asymptomatic, but the parasite can prove to be lethal when it infects immunocompromised individuals. Hemolysis and anemia are two common symptoms that accompany many infectious diseases, and this is particularly true of parasitic diseases that target red cells. Clinically, this becomes an acute problem for subjects who are prone to hemolysis and depend on frequent transfusions, like patients with sickle cell anemia or thalassemia. Little is known about Babesia’s pathogenesis in these hemoglobinopathies, and most parallels are drawn from its evolutionarily related Plasmodium parasite which shares the same environmental niche, the RBCs, in the human host. In vitro as well as in vivo Babesia-infected mouse sickle cell disease (SCD) models support the inhibition of intra-erythrocytic parasite proliferation, but mechanisms driving the protection of such hemoglobinopathies against infection are not fully studied. This review provides an overview of our current knowledge of Babesia infection and hemoglobinopathies, focusing on possible mechanisms behind this parasite resistance and the clinical repercussions faced by Babesia-infected human hosts harboring mutations in their globin gene.
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影响因子：
6.5
作者：
Goheen MM;Campino S;Cerami C
通讯作者：
Cerami C
影响因子：
10.1
作者：
Cursino-Santos, Jeny R.;Singh, Manpreet;Lobo, Cheryl A.
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Lobo, Cheryl A.
DOI：
10.1073/pnas.75.4.1994
发表时间：
1978-01-01
影响因子：
11.1
作者：
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通讯作者：
FRIEDMAN, MJ
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
20.3
作者：
Bunn, H. Franklin
通讯作者：
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