Gastric acid hypersecretory states: recent insights and advances.
Gastric acid hypersecretory states: recent insights and advances.
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DOI：
10.1007/s11894-009-0067-6
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发表时间：
2009-12
影响因子：
--
通讯作者：
Jensen RT
中科院分区：
文献类型：
--
作者：
Osefo N;Ito T;Jensen RT
Gastric acid hypersecretory states are a group of disorders characterized by basal hypersecretion of gastric acid and historically include a number of disorders associated with hypergastrinemia, hyperhistaminemia and of unknown etiology. Although gastric acid secretion is infrequently measured, it is important to recognize the role of gastric hypersecretion in the symptomatology of these disorders because they share a number of features of symptom pathogenesis and in treatment. In this article recent important articles reporting insights into their diagnosis, pathogenesis and treatment are reviewed. Particular attention is paid to Zollinger-Ellison syndrome, because it has the most extreme acid hypersecretion of this group of disorders and because of the large number of recent articles dealing with various aspects of the diagnosis, molecular pathogenesis or treatment of the gastrinoma itself or the acid hypersecretion. Two new hypersecretory disorders including rebound acid hypersecretion after the use of PPIs and acid hypersecretion with cysteamine treatment in children with cytinosis are also reviewed.
