Effects of angiotensins II and IV on blood pressure, renal function, and PAI-1 expression in the heart and kidney of the rat
Effects of angiotensins II and IV on blood pressure, renal function, and PAI-1 expression in the heart and kidney of the rat
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DOI：
10.1159/000063252
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发表时间：
2002-09-01
期刊：
影响因子：
3.1
通讯作者：
Brooks, DP
中科院分区：
文献类型：
--
作者：
Abrahamsen, CT;Pullen, M;Brooks, DP
在体内研究了血管紧张素II（AII）和血管紧张素IV（AIV）作为高血压期间派-1表达诱导剂的作用。2周输注All（300 ng/kg/min）通过渗透泵升高收缩压（171 +/- 2 vs. 138 +/- 6 mm Hg），尿蛋白排泄（32 +/- 6 vs 14 +/- 2 mg/天）、肾脏（2.2 +/- 0.5 vs 1.0 +/- 0.1）和心脏（1.8 +/- 0.3 vs 1.0 +/- 0.1）纤溶酶原激活物抑制剂1（派-1）基因表达。AN输注不影响上述任何一项，除了左心室中派-1基因表达增加（1.7 +/- 0.3 vs. 1.0 +/- 0.1）。所有输注大鼠均显示肌酐清除率降低（538 75与898 96 ml/min）和左心室肥厚（0.275 +/- 0.006与0.220 +/- 0.011 g/100 g）。我们的研究结果表明，所有但不是AN输注与肾派-1基因表达增加。版权所有（C）2002 S. Karger AG，巴塞尔。
The role of angiotensin II (AII) and angiotensin IV (AIV) as inducers of PAI-1 expression during hypertension was studied in vivo. A 2-week infusion of All (300 ng/kg/min) via an osmotic pump increased systolic blood pressure (171 +/- 2 vs. 138 +/- 6 mm Hg), urinary protein excretion (32 +/- 6 vs. 14 +/- 2 mg/day), and renal (2.2 +/- 0.5 vs. 1.0 +/- 0.1) and cardiac (1.8 +/- 0.3 vs. 1.0 +/- 0.1) gene expression of plasminogen activator inhibitor 1 (PAI-1). AN infusion did not affect any of the above with the exception of PAI-1 gene expression which was increased in the left ventricles (1.7 +/- 0.3 vs. 1.0 +/- 0.1). All-infused rats displayed a decreased creatinine clearance (538 75 vs. 898 96 ml/min) and hypertrophic left ventricles (0.275 +/- 0.006 vs. 0.220 +/- 0.011 g/100 g). Our results demonstrate that All but not AN infusion is associated with increased renal PAI-1 gene expression. Copyright (C) 2002 S. Karger AG, Basel.