Risk factors for conjunctival squamous cell neoplasia: a matched case-control study
Risk factors for conjunctival squamous cell neoplasia: a matched case-control study
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结膜鳞状细胞瘤形成的危险因素：匹配的病例对照研究
DOI：
10.1136/bjo.87.4.396
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发表时间：
2003
影响因子：
4.1
通讯作者：
S. Karnsawai
中科院分区：
文献类型：
--
作者：
W. Tulvatana;P. Bhattarakosol;L. Sansopha;W. Sipiyarak;E. Kowitdamrong;T. Paisuntornsug;S. Karnsawai
目的：目的探讨人乳头瘤病毒（HPV）感染和日光性弹性组织变性作为结膜鳞状细胞瘤（CSCN）危险因素的作用。研究方法：从组织档案中检索到30个连续病理标本，范围从结膜上皮内瘤变、原位癌到浸润性鳞状细胞癌。30个对照是来自接受囊外白内障摘除术的年龄和性别匹配的患者的无病结膜。两名蒙面病理学家研究了石蜡包埋结膜组织上的苏木精和伊红染色。与阴性和阳性对照相比，日光性弹性组织变性的弹性染色被盲解。用聚合酶链反应和斑点杂交技术检测HPV感染。结果：CSCN患者的平均年龄为54.9岁。男女比例为1：1。日光性弹性组织变性见于53.3%的CSCN和3.3%的对照组，比值比为16.0（95% CI，2.49至670.96; p值= 0.0003）。所有标本均未检出HPV DNA。结论：日光性弹性组织变性在CSCN患者中的发生率明显高于对照组，是CSCN的一个危险因素。这些数据不足以得出结论，HPV感染是CSCN的危险因素。
Aims: To identify roles of human papillomavirus (HPV) infection and solar elastosis as the risk factors for conjunctival squamous cell neoplasia (CSCN). Methods: 30 consecutive pathological specimens, ranging from conjunctival intraepithelial neoplasia, carcinoma in situ, to invasive squamous cell carcinoma were retrieved from tissue archives. 30 controls were disease free conjunctiva from age and sex matched patients undergoing extracapsular cataract extraction. Two masked pathologists studied haematoxylin and eosin stains on paraffin embedded conjunctival tissues. Elastic stain for solar elastosis was blindly interpreted in comparison with negative and positive controls. HPV infection was studied by polymerase chain reaction and dot hybridisation. Results: The mean age of CSCN patients was 54.9 years. The male to female ratio was 1:1. Solar elastosis was seen in 53.3% of CSCN and in 3.3% of controls with an odds ratio of 16.0 (95% CI, 2.49 to 670.96; p value = 0.0003). HPV DNA were not detected in any of the specimens. Conclusion: Solar elastosis is much more frequently found in CSCN cases than in their matched controls and is a risk factor for CSCN. These data are insufficient to conclude that HPV infection is a risk factor for CSCN.