Indole-N-Carboxylic Acids and Indole-N-Carboxamides in Organic Synthesis.
Indole-N-Carboxylic Acids and Indole-N-Carboxamides in Organic Synthesis.
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DOI：
10.1002/asia.201901806
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发表时间：
2020-02
期刊：
影响因子：
--
通讯作者：
Linwei Zeng;Yuxin Lin;Sunliang Cui
中科院分区：
文献类型：
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作者：
Linwei Zeng;Yuxin Lin;Sunliang Cui
吲哚是天然产物和生物活性分子中普遍存在的结构。吲哚类化合物的合成及吲哚类化合物的合成方法一直是有机化学中的研究热点。吲哚-N-羧酸及其衍生物吲哚-N-酰胺是一类非常有趣的化合物，在有机合成中有着广泛的应用，特别是在多组分反应和吲哚的C-H官能化反应中。本文综述了吲哚-N-羧酸和吲哚-N-酰胺类化合物在有机化学中的新反应，并讨论了该领域的合成潜力和发展前景。
Indoles are ubiquitous structures that distribute in natural products and biologically active molecules. The synthesis of indoles and indole-involved synthetic methodologies in organic chemistry receive considerable attention all the time. Indole-N-carboxylic acids and derived indole-N-carboxamides are intriguing compounds, which have been widely used in organic synthesis, especially in multicomponent reactions and C-H functionalization of indoles. This Minireview summarizes the advances of novel reactions involving indole-N-carboxylic acids and indole-N-carboxamides in organic chemistry, and discusses the synthetic potential and perspective of this field.