Research of the influence of the LIG4 gene polymorphism on the chromosomal aberration level in human lymphocytes, with background and excessive exposure to a radon
Research of the influence of the LIG4 gene polymorphism on the chromosomal aberration level in human lymphocytes, with background and excessive exposure to a radon
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氡背景和过量暴露下LIG4基因多态性对人淋巴细胞染色体畸变水平影响的研究
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
A. Larionov
中科院分区：
文献类型：
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作者：
A. Volkov;V. Druzhinin;V. Minina;T. Golovina;A. Timofeyeva;A. Larionov
LIG 4基因多态性rs 1805388（Thr 9 lle）和rs 1805389（Ala 3Val）对外周血淋巴细胞中染色体畸变水平的影响进行了估计，在正常和超常氡暴露条件下生活和学习的儿童在几个地点在克麦洛夫州。未显示使用标记rs 1805388的基因型组之间的细胞遗传学值的统计学显著差异。同时，在来自我们分析的第二组群的瓦尔携带者（标记rs 1805389）组中，与纯合子Ala/Ala相比，配对片段的量显著增加。
The effects of LIG4 gene polymorphisms rs1805388 (Thr9lle) and rs1805389 (Ala3Val) on the level of chromosomal aberrations in the lymphocytes of peripheral blood was estimated for children that live and study in conditions of normal and supernormal radon exposure in several locations in Kemerovskaya oblast. A statistically significant difference of the cytogenetic values among genotypic groups with the use of marker rs1805388 was not shown. At the same time, in the group of Val carriers (marker rs1805389) from the second cohort of our analysis revealed a significant increase of the amount of paired fragments in comparison to homozygotes Ala/Ala.
影响因子：
10.4
作者：
Au, William W;Salama, Salama A;Sierra-Torres, Carlos H
通讯作者：
Sierra-Torres, Carlos H