Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles
Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles
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DOI：
10.1016/j.jbior.2014.04.003
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发表时间：
2014-01-01
影响因子：
--
通讯作者：
Proud, Christopher G.
中科院分区：
文献类型：
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作者：
Kenney, Justin W.;Moore, Claire E.;Proud, Christopher G.
真核细胞延伸因子2激酶（eEF 2K）是一个非典型的“α-激酶”的小组成员。它磷酸化并抑制真核延伸因子2，以减缓蛋白质合成的延伸阶段，该阶段通常消耗大量能量和氨基酸。eEF 2K的活性通常依赖于钙离子和钙调蛋白。eEF 2K还受到大量其他输入的调节，包括通过合成代谢信号传导途径下游的信号传导的抑制，例如雷帕霉素复合物1的哺乳动物靶标。最近的数据表明，eEF 2K有助于保护癌细胞免受营养饥饿，并且在其他环境中也具有细胞保护作用，包括缺氧。越来越多的证据表明eEF 2K在神经过程中的作用，如学习和记忆，也许在抑郁症中。(C)2014由Elsevier Ltd.出版
Eukaryotic elongation factor 2 kinase (eEF2K) is a member of the small group of atypical 'alpha-kinases'. It phosphorylates and inhibits eukaryotic elongation factor 2, to slow down the elongation stage of protein synthesis, which normally consumes a great deal of energy and amino acids. The activity of eEF2K is normally dependent on calcium ions and calmodulin. eEF2K is also regulated by a plethora of other inputs, including inhibition by signalling downstream of anabolic signalling pathways such as the mammalian target of rapamycin complex 1. Recent data show that eEF2K helps to protect cancer cells against nutrient starvation and is also cytoprotective in other settings, including hypoxia. Growing evidence points to roles for eEF2K in neurological processes such as learning and memory and perhaps in depression. (C) 2014 Published by Elsevier Ltd.