PROSTAGLANDIN-E2 AS STIMULATOR OF HEMOPOIETIC STEM-CELL PROLIFERATION
PROSTAGLANDIN-E2 AS STIMULATOR OF HEMOPOIETIC STEM-CELL PROLIFERATION
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DOI：
10.1038/247550a0
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发表时间：
1974-01-01
期刊：
影响因子：
64.8
通讯作者：
GIDALI, J
中科院分区：
文献类型：
--
作者：
FEHER, I;GIDALI, J
尽管已经提出了几种细胞类型的洋地黄素和环AMP系统之间的严格相关性，并且环AMP的促有丝分裂作用也已被证明1，2，但洋地黄素的有丝分裂作用仅在某些细胞系统中得到证实3。此外，对芦荟素的造血作用知之甚少。如Dukes所证实的，在体外，几种洋地黄素，特别是PGE 2，可增强59 Fe和14 C-氨基葡萄糖掺入骨髓细胞，并增强促红细胞生成素的作用。我们研究了前列腺素E_（2-）对造血干细胞（脾集落形成单位）增殖状态的影响。
ALTHOUGH a strict correlation between prostaglandins and the cyclic AMP system has been suggested for several cell types, and the mitogenic effect of cyclic AMP has also been proved1,2, the mitotic effect of prostaglandins has been demonstrated only for some cell systems3. Also, little is known about the haemopoietic effect of prostaglandins. As proved by Dukes4, several prostaglandins, especially PGE2, enhance the59Fe and14C-glucosamine incorporation into bone marrow cells and potentiate the effect of erythropoietin,in vitro. We have studied the effect of PGE2on the proliferative state of haemopoietic stem cells (spleen colony forming units:CFU).