Pain in IBD Patients: Very Frequent and Frequently Insufficiently Taken into Account.
Pain in IBD Patients: Very Frequent and Frequently Insufficiently Taken into Account.
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IBD患者的疼痛：非常频繁且经常考虑不足。
DOI：
10.1371/journal.pone.0156666
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Swiss IBD Cohort Study Group
中科院分区：
文献类型：
--
作者：
Zeitz J;Ak M;Müller-Mottet S;Scharl S;Biedermann L;Fournier N;Frei P;Pittet V;Scharl M;Fried M;Rogler G;Vavricka S;Swiss IBD Cohort Study Group
疼痛是炎症性肠病（IBD）的常见症状。除了腹痛，疼痛也可以是IBD的肠外表现。疼痛治疗具有挑战性，相当一部分IBD患者接受阿片类药物治疗。因此，更好地了解疼痛症状对于更好地治疗这种临床问题至关重要。瑞士IBD队列研究（SIBDCS）的患者（n = 2152）接受了关于疼痛强度、疼痛定位以及疼痛对日常生活和社会活动影响的问卷调查。此外，问卷调查了疼痛特异性药物的使用情况。绝大多数患者（71%）在病程中经历疼痛。对于相当一部分患者（49%的UC患者和55%的CD患者），疼痛是一个长期存在的问题（>5年）。UC患者的疼痛持续时间短于CD患者（p < 0.01）。腹痛（59.5%）和背痛（38.3%）是主要的疼痛部位。67%的患者服用止痛药; 24%的患者没有接受止痛治疗。疼痛患者的总体生活质量显著低于无疼痛患者（38 vs. 77;（-100非常差; 100非常好）p<0.0001）。SIBDCS患者的疼痛患病率很高。这是一个长期存在的问题，对大多数患者的影响。疼痛被发现在SIBDCS治疗不足，并与健康相关的生活质量显着相关。因此，必须提高认识，以解决IBD过程中的这种常见并发症。
Pain is a common symptom related to inflammatory bowel disease (IBD). In addition to abdominal pain, pain can also be an extraintestinal manifestation of IBD. Pain treatment is challenging and a substantial part of IBD patients are treated with opioids. Therefore, a better knowledge on pain symptoms is crucial for a better therapeutic approach to this clinical problem. Patients of the Swiss IBD Cohort Study (SIBDCS) (n = 2152) received a questionnaire regarding pain intensity, pain localization and impact of pain on daily life and social activities. Furthermore, the questionnaire investigated the use of pain-specific medication. A vast majority of patients (71%) experienced pain during the disease course. For a substantial part of patients (49% in UC and 55% in CD) pain is a longstanding problem (>5 years). Pain in UC was of shorter duration compared to CD (p < 0.01). Abdominal pain (59.5%) and back pain (38.3%) were the main pain localizations. 67% of patients took pain medication; 24% received no pain treatment. The general quality of life was significantly lower in patients suffering of pain compared to those without pain (38 vs. 77; (-100 very bad; 100 very good) p<0.0001). Prevalence of pain is high in patients of the SIBDCS. It is a longstanding problem for the majority of the patients affected. Pain was found to be undertreated in the SIBDCS and was significantly associated with health-related quality of life. Thus, an increased awareness is mandatory to address this frequent complication in the course of IBD.