Impact of metabolic syndrome on the development of cardiovascular disease in a general Japanese population - The Hisayama study
Impact of metabolic syndrome on the development of cardiovascular disease in a general Japanese population - The Hisayama study
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DOI：
10.1161/strokeaha.106.479642
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发表时间：
2007-07-01
期刊：
影响因子：
8.3
通讯作者：
Kiyohara, Yutaka
中科院分区：
文献类型：
--
作者：
Ninomiya, Toshiharu;Kubo, Michiaki;Kiyohara, Yutaka
背景和目的-代谢综合征（MetS）与普通人群心血管疾病（CVD）事件风险增加相关。但是，在这方面，在亚洲人群中设计良好的前瞻性研究非常有限。方法-我们前瞻性地评估了1988年至2002年期间2452名年龄在40岁或40岁以上的日本社区居民，并检查了经修改的国家胆固醇教育计划成人治疗小组III标准定义的MetS对事件CVD的影响。结果-MetS的患病率为21%。在男性和女性中分别为30%和30%。在随访期间，发生了307例CVD事件。与无MetS的受试者相比，MetS受试者的年龄校正CVD发病率（每1000人-年）在男性（21.8比11.6，P < 0.01）和女性（12.9比6.5，P < 0.01）中均显著较高。即使在调整了以下混杂因素后，CVD事件的风险仍显著较高：年龄、蛋白尿、心电图异常、血清总胆固醇、吸烟习惯、饮酒和规律运动（男性风险比为1.86; 95%CI为1.32 - 2.62，女性风险比为1.70; 95%CI为1.22 - 2.36）。发现事件CVD的风险随着MetS组分的数量而增加，并且当组分的数量达到3时变得具有显著预测性。当CVD被分为冠心病和stroke.Conclusions -我们的研究结果表明，代谢综合征是一个显着的危险因素，在日本中年人群的心血管疾病的发展。
Background and Purpose - The metabolic syndrome (MetS) is associated with an increased risk of cardiovascular disease (CVD) events in general populations. However, well-designed prospective studies in Asian populations are very limited.Methods - We prospectively evaluated a total of 2452 community-dwelling Japanese individuals aged 40 years or older from 1988 to 2002 and examined the effects of MetS defined by the modified National Cholesterol Education Program Adult Treatment Panel III criteria on incident CVD.Results - The prevalence of the MetS was 21% in men and 30% in women at baseline. During the follow up, 307 CVD events occurred. Compared with those without MetS, the age-adjusted incidence of CVD (per 1000 person-years) was significantly higher in subjects with the MetS in both men (21.8 versus 11.6, P < 0.01) and women (12.9 versus 6.5, P < 0.01). The risk of CVD events was significantly higher even after adjusting for the following confounding factors: age, proteinuria, electrocardiographic abnormalities, serum total cholesterol, smoking habits, alcohol intake, and regular exercise (hazard ratio, 1.86; 95% CI, 1.32 to 2.62 in men and hazard ratio, 1.70; 95% CI, 1.22 to 2.36 in women). The risk of incident CVD was found to increase with the number of components of MetS and became significantly predictive when the number of components reached 3. Similar associations were also observed when CVD was divided into coronary heart disease and stroke.Conclusions - Our findings suggest that MetS is a significant risk factor for the development of CVD in the Japanese middle-aged population.