Immunotoxicity and Environment: Immunodysregulation and Systemic Inflammation in Children
Immunotoxicity and Environment: Immunodysregulation and Systemic Inflammation in Children
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DOI：
10.1177/0192623308329340
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发表时间：
2009-02-01
影响因子：
1.5
通讯作者：
Maronpot, Robert R.
中科院分区：
文献类型：
--
作者：
Calderon-Garciduenas, Lilian;Macias-Parra, Mercedes;Maronpot, Robert R.
环境污染物、化学品和药物会影响儿童免疫系统的发育。墨西哥城（MC）暴露于高浓度空气污染物的儿童表现出慢性呼吸道炎症、全身炎症、神经炎症和认知缺陷。我们测试了这样一个假设：暴露于严重空气污染中对无症状、表面上健康的儿童的免疫反应起作用。对来自墨西哥西南部城 (SWMC) (n = 66) 和标准污染物水平低于当前标准的对照城市 (n = 93) 的两组匹配儿童（年龄 9.7 +/- 1.2 岁）进行了免疫功能标记物、炎症介质和与脂多糖识别复合物相互作用的分子的血液测量。 MC 儿童的自然杀伤细胞数量显着减少 (p = .003)，mCD14+ 单核细胞数量显着增加 (p = .003)
Environmental pollutants, chemicals, and drugs have an impact on children's immune system development. Mexico City (MC) children exposed to significant concentrations of air pollutants exhibit chronic respiratory inflammation, systemic inflammation, neuroinflammation, and cognitive deficits. We tested the hypothesis that exposure to severe air pollution plays a role in the immune responses of asymptomatic, apparently healthy children. Blood measurements for markers of immune function, inflammatory mediators, and molecules interacting with the lipopolysaccharide recognition complex were obtained from two cohorts of matched children (aged 9.7 +/- 1.2 years) from southwest Mexico City (SWMC) (n = 66) and from a control city (n = 93) with criteria pollutant levels below current standards. MC children exhibited significant decreases in the numbers of natural killer cells (p = .003) and increased numbers of mCD14+ monocytes (p