Insulin-like growth factor 1 and muscle growth: implication for satellite cell proliferation
Insulin-like growth factor 1 and muscle growth: implication for satellite cell proliferation
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DOI：
10.1079/pns2004354
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发表时间：
2004-05-01
影响因子：
7
通讯作者：
Booth, FW
中科院分区：
文献类型：
--
作者：
Machida, S;Booth, FW
胰岛素样生长因子1（IGF-1）已被证明可以通过激活卫星细胞来挽救与衰老相关或失活诱导的肌肉质量损失。然而，IGF-1影响卫星细胞的信号通路和机制尚未完全确定。本综述的目的是提供目前的理解IGF-1诱导的卫星细胞增殖的细胞和分子事件的基础。
Insulin-like growth factor 1 (IGF-1) has been shown to rescue the aging-related or inactivity-induced loss of muscle mass through the activation of satellite cells. However, the signalling pathways and the mechanism by which IGF-1 affects satellite cells have not been not completely identified. The purpose of the present review is to provide current understanding of the cellular and molecular events underlying IGF-1 induced proliferation of satellite cells.