Galectins in the Tumor Microenvironment: Focus on Galectin-1
Galectins in the Tumor Microenvironment: Focus on Galectin-1
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DOI：
10.1007/978-3-030-43093-1_2
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发表时间：
2020-01-01
期刊：
影响因子：
--
通讯作者：
Navarro, Pilar
中科院分区：
文献类型：
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作者：
Martinez-Bosch, Neus;Navarro, Pilar
在过去的几十年中，癌症研究的重点已经从上皮细胞转移到肿瘤环境，以更好地了解肿瘤的发展和进展，并实现将这些知识转化为有效疗法的重要最终目标。聚糖结合蛋白的半乳糖凝集素家族在癌症的发生和进展中显示出重要的功能。许多研究小组为加深我们对半乳糖凝集素在肿瘤间质串扰中的作用的认识做出了杰出贡献，将其定义为调节肿瘤细胞与细胞外基质、成纤维细胞、内皮细胞和免疫系统之间相互作用的关键参与者。尽管到目前为止，该家族的几位成员一直受到特别关注，但其他人仍然被认为是未来的爆炸之星。本章对半乳糖凝集素 1 进行了概述，它是第一个被发现的、目前仍然是研究最深入的半乳糖凝集素之一，并强调了其在许多不同肿瘤类型中调节肿瘤微环境的非常重要的意义。此外，还提供了其他半乳糖凝集素在肿瘤环境中的作用的一瞥。更深入地了解半乳糖凝集素-1 的众多作用不仅有助于我们更好地了解其他半乳糖凝集素，而且还可能有助于开发更有效的癌症疗法。
In the last decades, the focus of cancer research has moved from epithelial cells to the tumor milieu, in an effort to better understand tumor development and progression, and with the important end goal of translating this knowledge into effective therapies. The galectin family of glycan-binding proteins displays important functions in cancer development and progression. Numerous groups have made outstanding contributions to deepen our knowledge about the role of galectins in the tumor-stroma crosstalk, defining them as key players in modulating interactions between tumor cells and the extracellular matrix, fibroblasts, endothelium, and the immune system. While several members of the family have been of particular interest until now, others are still considered as future exploding stars. This chapter provides an overview for galectin-1, the first identified and still one of themostwell-studied galectins, and highlights the very important implications in its regulation of the tumor microenvironment in many different tumor types. Besides, a glimpse of the role of other galectins in the tumor milieu is also provided. Gaining a deeper understanding about the numerous roles of galectin-1 will not only help us to better understand other galectins but also is likely to result in the development of more effective cancer therapies.