Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfection
Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfection
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DOI：
10.1016/j.vaccine.2003.12.024
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发表时间：
2004-07-29
期刊：
影响因子：
5.5
通讯作者：
Hamada, S
中科院分区：
文献类型：
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作者：
Okamoto, S;Kawabata, S;Hamada, S
鼻内感染非致死性甲型流感病毒（IAV），然后感染A组链球菌（GAS），可诱导小鼠的侵袭性致死性GAS感染，包括坏死性筋膜炎。我们证明，皮下免疫的福尔马林灭活的IAV疫苗或鼻内免疫的IAV疫苗和霍乱毒素保护超过75%的小鼠死亡的致命IAV-GAS重叠感染。存活率的增加与IAV中和活性和血清抗IAV IgG水平的增加相关。此外，从接种疫苗的小鼠的肺中消除IAV导致与肺泡上皮细胞相关的GAS耗尽。这些发现表明，福尔马林活化的IAV疫苗可能有助于预防先前IAV暴露后的继发性细菌感染。(C)2004 Elsevier Ltd.保留所有权利。
Intranasal infection with non-lethal influenza A virus (IAV) followed by infection with group A streptococci (GAS) induces invasive, lethal GAS infections, including necrotizing fasciitis, in mice. We demonstrate that subcutaneous immunization of formalin-inactivated IAV vaccine or intranasal immunization of IAV vaccine and cholera toxin protected more than 75% of mice from death by lethal IAV-GAS superinfection. The increased survival rate correlates with increase in IAV neutralizing activity and the levels of serum anti-IAV IgG. Moreover, elimination of IAV from the lungs of vaccinated mice led to depletion of GAS associated with alveolar epithelial cells. These findings suggest that formalin-in activated IAV vaccine may be useful for prevention of secondary bacterial infections following prior IAV exposure. (C) 2004 Elsevier Ltd. All rights reserved.