Antibody response to chlamydial heat shock protein 60 is strongly associated with acute coronary syndromes
Antibody response to chlamydial heat shock protein 60 is strongly associated with acute coronary syndromes
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DOI：
10.1161/01.cir.0000078632.76653.6c
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发表时间：
2003-06-24
期刊：
影响因子：
37.8
通讯作者：
Maseri, A
中科院分区：
文献类型：
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作者：
Biasucci, LM;Liuzzo, G;Maseri, A
热休克蛋白（HSPs）是一类具有免疫原性和促炎性的蛋白质。方法和结果：我们检测了179例不稳定型心绞痛、40例急性心肌梗死、40例稳定型心绞痛（SA）和100例对照组患者的抗Cp-HSP 60和抗Cp免疫球蛋白G（IgG）水平。41例急性冠状动脉综合征（ACS）患者在随访时也进行了研究。我们还测量了血浆高敏C反应蛋白（hs-CRP）和肌钙蛋白T（TnT）水平。在99%的ACS患者中发现了Cp-HSP 60的血清阳性，但在SA患者中仅为20%，而对照组中无一例。在67%的ACS患者、60%的SA患者和30%的对照受试者中检测到Cp血清阳性。心肌梗死组与不稳定型心绞痛组的Cp-HSP 60 IgG和Cp IgG无显著性差异。Cp-HSP 60 IgG、TnT和hs-CRP之间或Cp IgG和hs-CRP之间未发现相关性。在ACS患者随访中，Cp-HSP 60 IgG从0.88 +/- 0.25下降到0.45 +/- 0.14任意单位（P < 0.0001），12例患者变为阴性。结论-Cp-HSP 60血清阳性似乎是ACS的一个非常敏感和特异的标志物，与Cp IgG抗体滴度或hs-CRP和TnT水平无关。其在不稳定性中的因果关系及其在ACS中的诊断作用值得进一步研究。
Background-Heat shock proteins (HSPs) are a family of proteins with immunogenic and proinflammatory properties. Human and Chlamydia pneumoniae (Cp) HSP60 were found in patients with stable coronary disease.Methods and Results - We measured the levels of anti - Cp- HSP60 and anti-Cp immunoglobulin G (IgG) in 179 patients with unstable angina, 40 with acute myocardial infarction, and 40 with stable angina ( SA), as well as 100 control subjects. Forty-one patients with acute coronary syndromes (ACS) were also studied at follow-up. We also measured plasma levels of high-sensitivity C-reactive protein (hs-CRP) and troponin T (TnT). Seropositivity to Cp- HSP60 was found in 99% of ACS patients but in only 20% of SA patients and none of the control subjects. Seropositivity to Cp was detected in 67% of ACS patients, 60% of SA patients, and 30% of the control subjects. No differences in Cp- HSP60 IgG and in Cp IgG were observed between patients with myocardial infarction and patients with unstable angina. No correlation was found between Cp- HSP60 IgG, TnT, and hs-CRP or between IgG against Cp and hs-CRP. In ACS patients at follow-up, Cp-HSP60 IgG decreased from 0.88 +/- 0.25 to 0.45 +/- 0.14 arbitrary units (P < 0.0001), becoming negative in 12 patients.Conclusions - Seropositivity for Cp- HSP60 appears to be a very sensitive and specific marker of ACS, unrelated to Cp IgG antibody titers or hs-CRP and TnT levels. Its causal involvement in instability and its diagnostic role in ACS deserve further study.