Modeling epidermal melanoma in mice: moving into new realms but with unexpected complexities.
Modeling epidermal melanoma in mice: moving into new realms but with unexpected complexities.
复制标题
小鼠表皮黑色素瘤建模：进入新领域，但具有意想不到的复杂性。
DOI：
10.1038/jid.2012.200
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Walker,GraemeJ
中科院分区：
文献类型：
--
作者：
Handoko,HerlinaY;Box,NeilF;Walker,GraemeJ
Histological localization of human and murine melanomas is very different. Most human melanomas are epidermal, invading the dermis during progression, whereas murine lesions are usually exclusively dermal. We recently took a mouse model of dermal melanoma (ArfÀ/À:: Tyr-NRASQ61K), in which melanocytes are rarely seen in the epidermis of normal or lesional skin, and combined it with an animal carrying epidermal melanocytes throughout life due to the overexpression of the Kit receptor ligand in keratinocytes (K14-
