Development of an MCG/MEG system for small animals and its noise reduction method
Development of an MCG/MEG system for small animals and its noise reduction method
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小动物MCG/MEG系统的研制及其降噪方法
DOI：
10.1088/1742-6596/97/1/012258
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发表时间：
2008
影响因子：
4.7
通讯作者：
G. Uehara
中科院分区：
文献类型：
--
作者：
M. Miyamoto;J. Kawai;Y. Adachi;Y. Haruta;K. Komamura;G. Uehara
准确捕获大鼠或小鼠的生物磁信号极大地有利于新医学和病理学的开发。为了提高小动物生物磁测量的效率和准确性，我们开发了专门针对小动物测量的生物磁测量系统。新开发了超导量子干涉装置（SQUID）传感器阵列和系统工作台，并将其集成到尺寸为1.3 m宽×0.7 m深×1.8 m高的可移动底盘中，容纳系统的所有主要部件。集成 9 通道低 Tc SQUID 磁力计阵列旨在提高空间分辨率，覆盖 8 mm × 8mm 测量区域。我们还开发了适合该系统的实时噪声消除方法。该方法的优点是降噪过程是实时进行的。我们使用安装在典型实验室环境中的测量系统证实了该方法的有效性。在电源线频率及其谐波下，测得降噪效果约为 16 dB。我们利用该系统采用实时降噪方法测量了小鼠的心磁图（MCG），保证了小动物MCG测量的可行性。
Accurate capture of the biomagnetic signals from a rat or a mouse greatly benefits the development of new medicine and pathology. In order to improve the efficiency and accuracy of biomagnetic measurement of small animals, we developed a biomagnetic measurement system specific to small animal measurement. A superconducting quantum interference device (SQUID) sensor array and a table for the system were newly developed and were integrated into a transportable chassis having dimensions of 1.3 m width × 0.7 m depth × 1.8 m height and housing all principal components for the system. The integrated 9ch low-Tc SQUIDs magnetometer array designed to improve spatial resolution covers 8 mm × 8mm measurement area. We have also developed a real-time noise canceling method suitable for this system. The advantage of this method is that the noise reduction process is carried out in real time. We have confirmed the efficacy of this method using the measurement system which was installed in typical laboratory environment. The noise reduction effect was measured to be roughly 16 dB at power line frequency and its harmonics. We measured an magnetocardiogram (MCG) of a mouse using the system with the real-time noise canceling method, and the feasibility of small animal MCG measurement was ensured.