Dietary intakes and nutritional status of children with sickle cell disease at the Princess Marie Louise Hospital, Accra - a survey
Dietary intakes and nutritional status of children with sickle cell disease at the Princess Marie Louise Hospital, Accra - a survey
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DOI：
10.1186/s40795-018-0241-z
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发表时间：
2018-01-01
期刊：
影响因子：
2
通讯作者：
Renner, Lorna Awo
中科院分区：
文献类型：
--
作者：
Boadu, Isaac;Ohemeng, Agartha;Renner, Lorna Awo
研究背景镰状细胞病（SCD）是一种常见于非洲人后裔的慢性遗传性血液病，给患病个体带来营养负担。这项研究的目的是确定的饮食摄入量和营养状况的儿童SCD.MethodThis是一个横断面研究，涉及120名儿童SCD年龄在3-12岁的儿科门诊部玛丽路易斯公主医院（PML）在阿克拉。半结构式问卷调查被用来获取参与者的人口统计学特征和临床数据，从他们的医疗记录。饮食数据是通过24小时饮食回忆和食物频率问卷获得的。身高和体重进行测量的参与者和他们的血红蛋白水平进行了测定，以评估他们的贫血status.ResultsIntakes的参与者低于建议的大多数营养素，特别是钙和抗氧化维生素（维生素C和E）。营养素摄入量随年龄增长而下降，HbSS基因型儿童符合膳食建议的倾向较低（aOR=0.45，95%CI：0.18，1.10; p=0.084）。超过三分之一的研究儿童（38%）营养不良，年龄较大的儿童与年龄较小的儿童相比更容易营养不良。与其他基因型相比，SS基因型儿童发育迟缓的可能性更大（aOR=3.48，95%CI：1.10，11.01）。结论SCD儿童营养不良普遍存在，因此需要制定综合管理措施，将营养治疗与医疗保健结合起来，以改善他们的营养状况。营养管理应侧重于富含钙的食物和抗氧化剂营养素，特别是维生素C和E，以减少红细胞快速溶血和慢性贫血。
BackgroundSickle cell disease (SCD) is a chronic genetic blood disorder common among people of African descent, which places nutritional burden among affected individuals. The aim of the study was to determine the dietary intake and nutritional status of children with SCD.MethodThis was a cross sectional study that involved 120 children with SCD aged 3-12 years at the paediatric outpatient department of Princess Marie Louise Hospital (PML) in Accra. A semi-structured questionnaire was used to take information on participant's demographic characteristics and clinical data were obtained from their medical records. Dietary data were obtained using 24-h dietary recall and food frequency questionnaire. Height and weight were measured for participants and their haemoglobin levels were determined to assess their anaemia status.ResultsIntakes of participants were below recommendations for most nutrients, particularly for calcium and antioxidant vitamins (vitamin C and E). Adequacy of nutrient intake declined with age and children with genotype HbSS had a lower tendency to meet dietary recommendations (aOR=0.45, 95% CI: 0.18, 1.10; p=0.084). More than a third of the study children (38%) were malnourished, with older children having a tendency to be malnourished compared to the younger ones. Children with the SS genotype were more likely to be stunted (aOR=3.48, 95% CI: 1.10, 11.01), compared to other genotypes.ConclusionMalnutrition is prevalent among children with SCD and hence there is the need to develop comprehensive management coupling nutritional therapy to medical care to improve their nutritional status. Nutritional management should focus much on calcium-rich foods and antioxidants nutrients particularly vitamin C and E to reduce rapid erythrocyte haemolysis and chronic anaemia.