Expiratory flow pattern following single-lung transplantation in emphysema.
Expiratory flow pattern following single-lung transplantation in emphysema.
复制标题
肺气肿单肺移植后的呼气流量模式。
DOI：
10.1164/ajrccm.150.6.7952633
复制
发表时间：
1994
影响因子：
24.7
通讯作者：
Ginns,LC
中科院分区：
文献类型：
--
作者：
Herlihy,JP;Venegas,JG;Systrom,DM;Greene,RE;McKusick,KA;Wain,JC;Ginns,LC
In single lung transplantation (SLT) recipients, a "plateau" of the maximal expiratory flow volume curve (MEFV) and a "biphasic" MEFV have been reported to reflect anastomosis pathology. A plateau is defined as constant airflow over a large expired volume early in the MEFV. A biphasic MEFV has an initial period of high flow followed by a terminal low flow phase. Models of expiratory flow limitation by wave speed, however, predict that the MEFV of SLT recipients with emphysema should both be biphasic and demonstrate a plateau even without anastomosis pathology. Review of the spirometries and clinical courses of our first ten patients receiving SLT for emphysema demonstrated a biphasic MEFV, and a plateau of the MEFV in all patients. No patient showed evidence of anastomosis pathology. Independent lung spirometries, generated by a novel technique, revealed that the initial high flow phase of the MEFV came from the transplanted lung and the terminal low flow from the native emphysematous lung. The location of the flow limitation was demonstrated to be immediately downstream from the anastomosis. Therefore, the MEFV of SLT recipients with emphysema routinely demonstrates both a biphasic pattern and a plateau, neither of which necessarily reflect anastomosis pathology.
