Fish consumption and stroke in men - 30-year findings of the Chicago Western Electric Study
Fish consumption and stroke in men - 30-year findings of the Chicago Western Electric Study
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DOI：
10.1161/01.str.27.2.204
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发表时间：
1996-02-01
期刊：
影响因子：
8.3
通讯作者：
Stamler, J
中科院分区：
文献类型：
--
作者：
Orencia, AJ;Daviglus, ML;Stamler, J
背景和目的鱼类摄入量与中风发病率或死亡率之间关系的证据很弱。这份报告探讨了鱼类消费与stroke.Methods队列的2107名男子年龄在40至55岁的芝加哥西部电力研究谁是免费的冠心病和中风，通过他们的第一次年度复查进行了调查，在基线鱼类摄入量和30年的致命性和非致命性中风的风险。1847名男性的基线鱼类摄入量数据分为四个水平（大于或等于35 g/d，18至34 g/d，1至17 g/d和0 g/d）。对前两次检查的宏量营养素和微量营养素的平均值以及主要的冠状动脉和中风风险因素与鱼类消费的关系进行了评估。中风死亡率确定从死亡证明和非致命性中风的记录的卫生保健融资Administration.Results在46 426人年的后续行动中，76中风死亡。男性消费大于或等于35克/天的鱼（最高水平）有较高的年龄调整后的中风死亡率（23.5每10000人年）比男性在其他三个类别的鱼类消费。基于校正年龄收缩压、吸烟、血清胆固醇水平、糖尿病、心电图异常和食盐使用的考克斯比例风险回归模型，（和95%置信区间）远鱼消费者与非消费者相比，（0.53 ~ 3.41），18 ~ 34 g/d为0.96（0.41 ~ 2.21），1 ~ 17 g/d为1.00（0.43 ~ 2.33）。致命性和非致命性中风（n=222）调整和多变量分析产生了类似的results.Conclusions中风率最高的亚组报告最高的鱼类摄入量，这些数据不支持假设的负相关的鱼类消费与中风。
Background and Purpose Evidence of a relationship of fish intake to stroke incidence or mortality is weak. This report examines the association of fish consumption with stroke.Methods A cohort of 2107 men aged 40 to 55 years from the Chicago Western Electric Study who were free of coronary heart disease and stroke through their first annual reexamination was investigated in relation to baseline fish intake and 30-year risk of fatal and nonfatal stroke. Data on baseline fish intake, categorized into four levels (greater than or equal to 35 g/d, 18 to 34 g/d, 1 to 17 g/d, and 0 g/d), were available for 1847 men. Average values of macronutrients and micronutrients from the first two examinations and major coronary and stroke risk factors were assessed in relation to fish consumption. Stroke mortality was ascertained from death certificates and nonfatal stroke from records of the Health Care Financing Administration.Results During 46 426 person-years of follow-up, 76 stroke deaths occurred. Men consuming greater than or equal to 35 g/d of fish (highest level) had a higher age-adjusted death rate from stroke (23.5 per 10 000 person-years) than men in the three other categories of fish consumption. Based on a Cox proportional hazards regression model with adjustment for age systolic blood pressure, cigarette smoking, serum cholesterol level, diabetes, electrocardiographic abnormalities, and table salt use, hazards ratios (and 95% confidence intervals) far fish consumers compared with nonconsumers were 1.34 (0.53 to 3.41) for greater than or equal to 35 g/d, 0.96 (0.41 to 2.21) for 18 to 34 g/d, and 1.00 (0.43 to 2.33) for 1 to 17 g/d. Age-adjusted and multivariate analyses for fatal and nonfatal strokes (n=222) yielded similar results.Conclusions With stroke rates highest in the subgroup reporting highest fish intake, these data do not support the hypothesis of an inverse association of fish consumption with strokes.