C-reactive protein genetics is associated with carotid artery compliance in men in The Cardiovascular Risk in Young Finns Study
C-reactive protein genetics is associated with carotid artery compliance in men in The Cardiovascular Risk in Young Finns Study
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DOI：
10.1016/j.atherosclerosis.2007.01.027
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发表时间：
2008-02-01
期刊：
影响因子：
5.3
通讯作者：
Hurme, M.
中科院分区：
文献类型：
--
作者：
Eklund, C.;Kivimaki, M.;Hurme, M.
虽然C反应蛋白（CRP）是已知的预测心血管事件，其作为一个因果风险因素的地位仍然存在争议。CRP基因单核苷酸多态性（SNPs）已被证明与CRP浓度相关，但没有直接的独立影响早期动脉粥样硬化的变化已被证明。我们的目的是确定CRP基因多态性或单倍型是否与CRP浓度或颈动脉顺应性（CAC）相关，CAC是亚临床动脉粥样硬化的指标：我们对CRP基因多态性- 717 > AG，-286 C> T > A，+10596 > C，+ 1444 C> T和+18466> A，并测量了2283名参加芬兰年轻人心血管风险研究的年轻人的CRP浓度和CAC。CRP基因型和CRP浓度之间存在很强的相关性，这也见于单倍型水平。线性回归分析显示，在调整危险因素后，每个SNP对CRP浓度的独立影响，男性中+1444除外。此外，-286 C> T > A、+1444 C> T和+18466 > A与男性CAC相关，而与女性CAC无关。携带SNP-286等位基因C的男性在调整风险因素后CAC增加。这些数据表明，高生产CRP基因型的存在是有害的男性颈动脉弹性。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Although C-reactive protein (CRP) is known to predict cardiovascular events, its status as a causal risk factor is still controversial. CRP gene single nucleotide polymorphisms (SNPs) have been shown to associate with CRP concentration, but no direct independent effect on early atherosclerotic changes has been demonstrated. We aimed to determine if CRP gene polymorphisms or haplotypes are associated with CRP concentration or carotid artery compliance (CAC), an indicator of subclinical atherosclerosis: We genotyped CRP gene polymorphisms - 717 > AG, - 286C > T > A, +10596 > C, +1444C > T and +18466 > A and measured CRP concentration and CAC in 2283 young adults participating in The Cardiovascular Risk in Young Finns Study. A strong association was found between CRP genotypes and CRP concentration, which was also seen at the haplotype level. Linear regression analysis showed an independent effect of each SNP on CRP concentration after adjustment for risk factors, except for +1444 in males. Moreover, - 286C > T > A, +1444C > T and +18466 > A were associated with CAC in males, but not in females. Men carrying the SNP -286 allele C had increased CAC after adjusting for risk factors. These data suggest that the presence of high producer CRP genotype is deleterious to carotid elasticity in men. (c) 2007 Elsevier Ireland Ltd. All rights reserved.