Prefrontal and parietal contributions to spatial working memory
Prefrontal and parietal contributions to spatial working memory
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DOI：
10.1016/j.neuroscience.2005.04.070
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发表时间：
2006-01-01
期刊：
影响因子：
3.3
通讯作者：
Curtis, CE
中科院分区：
文献类型：
--
作者：
Curtis, CE
功能性神经影像学研究一致表明，人类大脑皮层存在一个广泛的网络，这些区域共同支持空间工作记忆。这篇综述总结了我们近期对进行延迟眼跳的人类所做的功能性磁共振成像研究。这些研究分离出在位置信息维持期间背侧前额叶区域（如额叶眼动区）以及后顶叶皮层的持续活动。我们的目的是深入了解这种活动所编码的信息类型。通过操纵工作记忆任务的感觉和运动需求，我们已经能够调节额叶眼动区和后顶叶皮层延迟期的活动。这些发现结合其他神经生理学和基于损伤的数据进行了讨论，并提出了一些关于额叶和顶叶区域对空间工作记忆的不同贡献的假设。即空间的回顾性感觉编码在后顶叶皮层可能更为显著，而空间的前瞻性运动编码在额叶眼动区可能更为显著。(C) 2005由爱思唯尔有限公司代表国际脑研究组织出版。
Functional neuroimaging studies consistently implicate a widespread network of human cortical brain areas that together support spatial working memory. This review summarizes our recent functional magnetic resonance imaging studies of humans performing delayed-saccades. These studies have isolated persistent activity in dorsal prefrontal regions, like the frontal eye fields, and the posterior parietal cortex during the maintenance of positional information. We aim to gain insight into the type of information coded by this activity. By manipulating the sensory and motor demands of the working memory task, we have been able to modulate the frontal eye fields and posterior parietal cortex delay-period activity. These findings are discussed in the context of other neurophysiological and lesion-based data and some hypotheses regarding the differential contributions of frontal and parietal areas to spatial working memory are offered. Namely, retrospective sensory coding of space may be more prominent in the posterior parietal cortex, while prospective motor coding of space may be more prominent in the frontal eye fields. (C) 2005 Published by Elsevier Ltd on behalf of IBRO.