Chronic comorbidities in persons living with HIV within three years of exposure to antiretroviral therapy at Pantang Antiretroviral Center in Ghana: a retrospective study.
Chronic comorbidities in persons living with HIV within three years of exposure to antiretroviral therapy at Pantang Antiretroviral Center in Ghana: a retrospective study.
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在加纳的潘坦抗逆转录病毒中心暴露于抗逆转录病毒疗法的三年内，患有HIV的人的慢性合并症：一项回顾性研究。
DOI：
10.11604/pamj.2022.42.294.35134
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
接受抗逆转录病毒疗法(ART)和继续接受护理与延长预期寿命有关，但会增加艾滋病毒携带者(PLWH)和服用抗逆转录病毒药物的人合并疾病的风险。这项研究描述了加纳PLWH之间的共病情况。从潘塘艺术中心随机抽取的900人中，222人参加了2020年6月至7月的研究。从PLWH的医疗记录中提取社会人口学特征、HIV生物标志物、用药类型和依从性，以及确诊的慢性疾病。采用COX比例风险模型和Kaplan-Meier曲线绘制并存条件的风险。在p<；0.05处进行对数等级检验。53.2%的PLWH(222例)合并有呼吸系统疾病(17.6%)、贫血(12.2%)、高血压(12.2%)、心血管疾病(10.8%)和神经系统疾病(10.8%)，与这些疾病相关的因素有呼吸系统疾病的用药依从性(AHR=0.43，95%CI：0.21~0.90)和视力改变(AHR=2.64，95%CI：1.08~6.45)、年龄(AHR=10.03，95%CI)；世界卫生组织临床分期(II期(AHR=13.36，95%CI=1.54~115.63)和III期(AHR=11.71，95%CI=1.41~97.26))。卡普兰-梅尔曲线显示，年龄、CD4计数≤350个/平方毫米、世卫组织临床第三和第四期以及ART未坚持的共病条件的显著风险。了解PLWH的合并症类型是向初级保健提供者提供反馈以进行监测不可或缺的一部分。
uptake of antiretroviral therapy (ART) and retention in care are associated with increased life expectancy but increased the risk of comorbid conditions in persons living with HIV (PLWH) and taking antiretroviral drugs. This study describes comorbid conditions among PLWH in Ghana. PLWH (n=222) out of a sample population of 900, randomly selected at Pantang ART Center participated in the study from June to July of 2020. Socio-demographic characteristics, HIV biomarkers, medication type and adherence, and diagnostic confirmed chronic conditions were extracted from medical records of PLWH. Cox proportional-hazard models and Kaplan-Meier curves graphing risk of experiencing comorbid conditions were performed. Log-rank test was performed at p<0.05. fifty three point two percent of PLWH (222) experienced a comorbid condition including, respiratory conditions (17.6%), anaemia (12.2%), hypertension (12.2%), cardiovascular diseases (10.8%),and neurological conditions (10.8%).Factors associated with some of these conditions were medication adherence (aHR=0.43, 95% CI: 0.21-0.90) and visual changes (aHR=2.64, 95% CI: 1.08-6.45) for respiratory conditions, age (aHR=10.03, 95% CI; 1.22-82.37) for hypertension, and World Health Organization (WHO) clinical stages (stage II (aHR=13.36, 95% CI=1.54-115.63) and III (aHR=11.71, 95% CI=1.41-97.26))for peripheral neuropathy. Kaplan-Meier curves show significant risk of comorbid conditions for age, CD4 count ≤350 cells/mm2, WHO clinical stages III and IV, and ART non-adherence. understanding the types of comorbidities in PLWH is integral to providing feedback to primary care providers to monitor.
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DOI：
10.2174/1874613601509010051
发表时间：
2015
期刊：
The open AIDS journal
影响因子：
--
作者：
Nsagha DS;Assob JC;Njunda AL;Tanue EA;Kibu OD;Ayima CW;Ngowe MN
通讯作者：
Ngowe MN
影响因子：
4.2
作者：
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通讯作者：
Iacobellis, Gialuca
DOI：
10.1177/2325958218821963
发表时间：
2019-01-01
影响因子：
--
作者：
Agbaji, Oche O.;Abah, Isaac O.;Kanki, Phyllis J.
通讯作者：
Kanki, Phyllis J.
DOI：
10.1177/1545109712456740
发表时间：
2014-01-01
影响因子：
--
作者：
Jain, Nirdesh;Reddy, Dandu H;Gupta, Alok
通讯作者：
Gupta, Alok
影响因子：
4.2
作者：
Jotwani, Vasantha;Scherzer, Rebecca;Shlipak, Michael
通讯作者：
Shlipak, Michael