The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation
The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation
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DOI：
10.1038/nsmb1283
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发表时间：
2007-09-01
影响因子：
16.8
通讯作者：
Jacobsen, Steven E.
中科院分区：
文献类型：
--
作者：
Zhang, Xiaoyu;Germann, Sophie;Jacobsen, Steven E.
在动物中，多梳蛋白通过组蛋白H3 Lys27三甲基化（H3K27me3）维持沉默的染色质状态，但在植物基因组中没有发现同源物。利用DamID芯片技术，我们发现拟南芥含染色结构域的蛋白LHP 1与H3K27me3在全基因组范围内共定位。LHP 1染色体结构域也以高亲和力结合H3K27me3，表明LHP 1具有与Polycomb相似的功能。
Polycomb proteins are required for maintenance of silent chromatin states via histone H3 Lys27 trimethylation ( H3K27me3) in animals, but homologs are not found in plant genomes. Using a DamID- chip method, we found that the Arabidopsis thaliana chromodomain- containing protein LHP1 colocalizes with H3K27me3 genome- wide. The LHP1 chromodomain also binds H3K27me3 with high affinity, suggesting that LHP1 has functions similar to those of Polycomb.