WYZ: a pilot study protocol for designing and developing a mobile health application for engagement in HIV care and medication adherence in youth and young adults living with HIV
WYZ: a pilot study protocol for designing and developing a mobile health application for engagement in HIV care and medication adherence in youth and young adults living with HIV
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DOI：
10.1136/bmjopen-2019-030473
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发表时间：
2019-05-01
期刊：
影响因子：
2.9
通讯作者：
Saberi, Parya
中科院分区：
文献类型：
--
作者：
Erguera, Xavier A.;Johnson, Mallory O.;Saberi, Parya
引言青少年和年轻人在艾滋病毒负担中所占的比例不成比例，迫切需要采取干预措施来遏制这些年龄组之间的健康差异。我们研究的目的是建立在我们的理论指导模型和形成性研究，以开发一个移动的健康应用程序，称为WYZ，以提高艾滋病毒护理和抗逆转录病毒治疗依从性的参与，并在青年和年轻的艾滋病毒感染者（YLWH）中进行试点测试。在本文中，我们解释了WYZ的设计和开发YLWH，描述了即将进行的试点试验的设计，以评估WYZ的可行性和可接受性，并将WYZ与其他正在开发的移动的健康应用程序进行比较，以提高艾滋病毒护理和抗逆转录病毒药物治疗的依从性。并在开发WYZ的beta测试期间获得反馈。WYZ是通过移动的电话提供的模块化、自适应和个性化干预。它以信息、动机、行为技能模型为基础，对于理解和指导复杂健康行为干预措施的制定非常有价值。WYZ是与18-29岁的YLWH合作创建的，采用以人为本的设计方法，强调理解技术用户的观点。WYZ旨在通过以下方式改善对艾滋病毒护理的参与：（1）提高药物依从性自我效能，（2）提高对社区资源的认识和使用，（3）减少青年与其医疗保健团队之间的沟通障碍，以及（4）为形成YLWH私人在线社区提供安全平台。我们将进行一项为期6个月的单组试点研究，以研究在旧金山弗朗西斯科湾区居住或接受护理的76名YLWH中实施WYZ的可行性和可接受性。所有研究活动，包括招募、筛选、入组、研究评估、提供奖励和离职面谈，都将远程进行。我们将使用定量和定性方法探索干预的可行性和可接受性结果。伦理和传播研究工作人员将获得所有参与者的书面同意书。本研究及其方案已获得加州大学旧金山弗朗西斯科（UCSF）机构审查委员会的批准。研究人员将与UCSF艾滋病预防研究中心的社区参与核心和青年咨询小组合作，利用演示文稿，社区论坛，期刊出版物和/或社交媒体向参与者和社区传播结果。
Introduction Youth and young adults bear a disproportionate share of the HIV burden and there is a critical need for interventions to curb health disparities experienced among these age groups. The purpose of our research is to build on our theory-guided model and formative research to develop a mobile health application, called WYZ, for improved engagement in HIV care and antiretroviral therapy adherence, and pilot test it among youth and young adults living with HIV (YLWH). In this paper, we explain the design and development of WYZ for YLWH, describe the design of a forthcoming pilot trial for evaluating the feasibility and acceptability of WYZ and compare WYZ with other mobile health applications being developed to improve engagement in HIV care and antiretroviral medication adherence.Methods and analysis We used an agile methodology, shown to be useful in software development, and elicited feedback during beta testing to develop WYZ. WYZ is a modular, adaptive and personalised intervention delivered via a mobile phone. It is grounded in the information, motivation, behaviouralskills model which has been valuable for understanding and guiding the development of interventions for complex health behaviours. WYZ was created in collaboration with YLWH aged 18-29 years using a human-centred design approach that emphasises understanding the perspective of the users of the technology. WYZ is intended to improve engagement in HIV care by: (1) enhancing medication adherence self-efficacy, (2) increasing awareness and use of community resources, (3) reducing barriers to communication between youth and their healthcare team, and (4) providing a secure platform for the formation of a private online community of YLWH. We will conduct a 6-month single-arm pilot study to examine feasibility and acceptability of WYZ among 76 YLWH who live or receive care in the San Francisco Bay Area. All study activities, including recruitment, screening, enrolment, study assessments, provision of incentives and exit interviews, will be conducted remotely. We will explore feasibility and acceptability outcomes of the intervention using quantitative and qualitative methods.Ethics and dissemination Study staff will obtain written consent for study participation from all participants. This study and its protocols have been approved by the University of California San Francisco (UCSF) Institutional Review Board. Study staff will work with the UCSF Center for AIDS Prevention Studies' Community Engagement Core and the Youth Advisory Panel to disseminate results to the participants and the community using presentations, community forums, journal publications and/or social media.