Modulation of neural activity during observational learning of actions and their sequential orders
Modulation of neural activity during observational learning of actions and their sequential orders
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DOI：
10.1523/jneurosci.3914-06.2006
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发表时间：
2006-12-20
影响因子：
5.3
通讯作者：
Gerry, Valerie E.
中科院分区：
文献类型：
--
作者：
Frey, Scott H.;Gerry, Valerie E.
大脑如何将对他人行为的感知表征转化为可用于指导行为的运动表征？在这里，我们使用功能性磁共振成像来记录人类的大脑活动，而受试者观看其他人在不同的任务要求下构建多部分物体。我们发现，相对于静息基线，被动动作观察增加了参与动作编码（镜像系统）的下额叶和顶叶皮质内的活动，并贯穿参与运动表征的区域的分布式网络，包括背侧运动前皮质、前辅助运动区、小脑和基底神经节（实验1和2）。相对于被动观察，这些相同的领域表现出增加的活动时，受试者观察的意图，随后再现组件的行动，使用演示的顺序程序（实验1）。观察相同的动作，目的是复制组件的行动，但不需要使用演示的顺序程序，增加活动在相同的区域，虽然在较小的程度（实验2）。这些发现表明，当试图通过观察来学习行为时，观察者的意图调节了广泛分布的皮层和皮层下区域网络中的反应，这些区域先前涉及动作编码和/或运动表征。在这些区域中，只有右侧顶内沟内的活动可以预测随后进行的观察程序的准确性。通过观察学习成功形成顺序程序的运动表征取决于在顶叶区域内实施的计算。
How does the brain transform perceptual representations of others' actions into motor representations that can be used to guide behavior? Here we used functional magnetic resonance imaging to record human brain activity while subjects watched others construct multipart objects under varied task demands. We find that relative to resting baseline, passive action observation increases activity within inferior frontal and parietal cortices implicated in action encoding ( mirror system) and throughout a distributed network of areas involved in motor representation, including dorsal premotor cortex, pre- supplementary motor area, cerebellum, and basal ganglia ( experiments 1 and 2). Relative to passive observation, these same areas show increased activity when subjects observe with the intention to subsequently reproduce component actions using the demonstrated sequential procedures ( experiment 1). Observing the same actions with the intention of reproducing component actions, but without the requirement to use the demonstrated sequential procedure, increases activity in the same regions, although to a lesser degree ( experiment 2). These findings demonstrate that when attempting to learn behaviors through observation, the observers' intentions modulate responses in a widely distributed network of cortical and subcortical regions implicated previously in action encoding and/ or motor representation. Among these regions, only activity within the right intraparietal sulcus predicts the accuracy with which observed procedures are subsequently performed. Successful formation of motor representations of sequential procedures through observational learning is dependent on computations implemented within this parietal region.