Methylprednisolone enhances contraction of porcine femoral head epiphyseal arteries
Methylprednisolone enhances contraction of porcine femoral head epiphyseal arteries
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DOI：
10.1097/01.blo.0000127587.92303.b4
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发表时间：
2004-06-01
影响因子：
4.2
通讯作者：
Hansen, ES
中科院分区：
文献类型：
--
作者：
Drescher, W;Bünger, MH;Hansen, ES
类固醇引起的股骨头坏死的病理机制被认为是股骨头血流紊乱。我们假设甲基强的松龙会增加股骨头骨骺动脉的血管收缩，从而减少股骨头血流量。从 18 头猪中随机选择 9 头未成熟的雌性家猪接受 24 小时甲基泼尼松龙治疗，而其余 9 头猪以盲法方式接受安慰剂对照。处死后，将股骨头的外侧骨骺动脉段作为环标本安装在小血管肌动描记器上。测量等长主动张力与血管收缩剂去甲肾上腺素和内皮素-1以及血管舒张剂缓激肽的累积剂量的关系。甲泼尼龙不改变去甲肾上腺素的血管收缩。缓激肽引起浓度依赖性血管舒张，这种舒张在皮质类固醇治疗的血管中较低。在皮质类固醇治疗的血管中，内皮素-1 的血管收缩作用更强。我们的数据表明，甲基强的松龙可增强股骨头外侧骨骺动脉的收缩，并可能减少股骨头血流量。据我们所知，股骨头坏死的这种病理力学因素以前从未被描述过。
The pathomechanism of steroid-induced femoral head necrosis is thought to be disturbed femoral head blood flow. We hypothesize that methylprednisolone increases vasocontraction of femoral head epiphyseal arteries, thereby reducing femoral head blood flow. Nine immature female domestic pigs were randomly selected from a group of 18 to receive 24-hour methylprednisolone treatment, whereas the nine remaining pigs received the placebo control in a blinded fashion. After sacrifice, lateral epiphyseal artery segments from the femoral heads were mounted as ring preparations on a small vessel myograph. Isometric active tension was measured in relation to cumulating doses of the vasoconstrictors noradrenaline and endothelin-1, and the vasodilator bradykinin. Vasocontraction to noradrenaline was not altered by methylprednisolone. Bradykinin elicited a concentration-dependent vasodilation which was lower in the corticosteroid-treated vessels. Vasoconstriction to endothelin-1 was stronger in the corticosteroid-treated vessels. Our data indicate that methylprednisolone enhances contraction of femoral head lateral epiphyseal arteries and may decrease femoral head blood flow. To our knowledge, this pathomechanic factor in femoral head necrosis has not been described before.