Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats:: reversal by insulin
Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats:: reversal by insulin
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DOI：
10.1152/ajpregu.1998.274.5.r1482
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发表时间：
1998-05-01
影响因子：
2.8
通讯作者：
Ahrén, B
中科院分区：
文献类型：
--
作者：
Havel, PJ;Uriu-Hare, JY;Ahrén, B
胰岛素调节循环瘦素的证据是相互矛盾的。用链脲佐菌素（STZ; 40 mg.kg（-1）.day（-1）× 2天）在大鼠中诱导糖尿病，以检查胰岛素缺乏型糖尿病和胰岛素治疗对循环瘦素的影响。12周后，未治疗组大鼠血浆瘦素浓度均低于对照组，
Evidence for regulation of circulating leptin by insulin is conflicting. Diabetes was induced in rats with streptozotocin (STZ; 40 mg.kg(-1).day(-1) x 2 days) to examine the effect of insulin-deficient diabetes and insulin treatment on circulating leptin. After 12 wk, plasma leptin concentrations in untreated rats were all