Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP.
Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP.
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DOI:
10.1177/15357597211004556
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发表时间:
2021-03-31
影响因子:
3.6
通讯作者:
Pavlova MK
中科院分区:
文献类型:
--
作者:
Buchanan GF;Gluckman BJ;Kalume FK;Lhatoo S;Maganti RK;Noebels JL;Simeone KA;Quigg MS;Pavlova MK
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Likely pathophysiological mechanisms include seizure-induced cardiac and respiratory dysregulation. A frequently identified feature in SUDEP cases is that they occur at night. This raises the question of a role for sleep state in regulating of SUDEP. An association with sleep has been identified in a number of studies with patients and in animal models. The focus of this section of the Sleep and Epilepsy Workshop was on identifying and understanding the role for sleep and time of day in the pathophysiology of SUDEP.
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