Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP.

Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP.
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DOI:
10.1177/15357597211004556
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发表时间:
2021-03-31
期刊:
影响因子:
3.6
通讯作者:
Pavlova MK
Pavlova MK
中科院分区:
医学3区
文献类型:
--
作者:
Buchanan GF;Gluckman BJ;Kalume FK;Lhatoo S;Maganti RK;Noebels JL;Simeone KA;Quigg MS;Pavlova MK

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癫痫猝死(SUDEP)是难治性癫痫患者死亡的主要原因。可能的病理生理机制包括癫痫引起的心脏和呼吸失调。 SUDEP 病例的一个常见特征是它们发生在夜间。这就提出了睡眠状态在调节 SUDEP 中的作用的问题。许多针对患者和动物模型的研究已确定其与睡眠的关联。睡眠和癫痫研讨会这一部分的重点是确定和理解睡眠和一天中的时间在 SUDEP 病理生理学中的作用。
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Likely pathophysiological mechanisms include seizure-induced cardiac and respiratory dysregulation. A frequently identified feature in SUDEP cases is that they occur at night. This raises the question of a role for sleep state in regulating of SUDEP. An association with sleep has been identified in a number of studies with patients and in animal models. The focus of this section of the Sleep and Epilepsy Workshop was on identifying and understanding the role for sleep and time of day in the pathophysiology of SUDEP.
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