Melatonin therapy in shift workers with difficulty falling asleep: A randomized, double-blind, placebo-controlled crossover field study
Melatonin therapy in shift workers with difficulty falling asleep: A randomized, double-blind, placebo-controlled crossover field study
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DOI：
10.3233/wor-162376
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发表时间：
2016-01-01
影响因子：
2.3
通讯作者：
Khajeh-Mehrizi, Ahmad
中科院分区：
文献类型：
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作者：
Sadeghniiat-Haghighi, Khosro;Bahrami, Hamid;Khajeh-Mehrizi, Ahmad
背景：睡眠障碍在轮班工作中很常见。目的：探讨夜间睡前30 min给予褪黑素3 mg对倒班工人入睡困难的治疗效果。方法：采用匹兹堡睡眠质量指数（PSQI）和失眠严重程度指数（ISI）对倒班工人进行调查。进行了一项随机、双盲、安慰剂对照的交叉研究，研究期间为3个晚上，洗脱期为2周，比较褪黑激素与安慰剂。结果：295名作业工人中有103名存在入睡困难，其中103名睡眠质量较差，睡眠质量较差的作业工人睡眠质量较差，睡眠质量较差的作业工人睡眠质量较差。最后，从随机抽取的50名入睡困难的工人中，39名工人完成了研究。与基线和服用安慰剂相比，褪黑激素治疗显著增加SE和降低SOL。SE从基线时的82.1%增加到褪黑激素治疗后的85.5%。SOL也从基线时的0.27小时降低到褪黑激素治疗后的0.20小时。结论：本研究表明，褪黑素治疗倒班工人入睡困难的睡眠起始潜伏期和睡眠效率显着改善。
BACKGROUND: Disturbed sleep is common in shift work. It is hypothesized that administration of exogenous melatonin could reduce the sleep latency and improve the sleep quality.OBJECTIVE: To evaluate the efficacy of 3 mg melatonin taken 30 min before night time sleep on shift workers with difficulty falling asleep.METHODS: Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) were applied to find out shift workers with difficulty falling asleep. A randomized, double-blind, placebo-controlled crossover study with periods of 3 night and washouts of 2 weeks comparing melatonin with placebo was performed. Night time sleep parameters obtained from somnowatch including total sleep time (TST), sleep onset latency (SOL), sleep efficiency (SE) and wakening after sleep onset (WASO) were analyzed.RESULTS: Among 295 workers, 103 had difficulty falling asleep. Finally, from 50 randomly selected workers with difficulty falling asleep, 39 workers completed the study. Melatonin treatment significantly increased SE and decreased SOL in comparison with baseline and taking placebo. SE was increased from 82.1% at baseline to 85.5% after melatonin therapy. Also SOL was decreased from 0.27 h at baseline to 0.20 h after melatonin therapy. Effects of Melatonin administration on TST and WASO were not significant.CONCLUSIONS: This study showed that melatonin therapy in shift workers with difficulty falling asleep significantly improved the sleep onset latency and sleep efficiency.