Fingertip representation in the human somatosensory cortex: An fMRI study
Fingertip representation in the human somatosensory cortex: An fMRI study
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DOI：
10.1006/nimg.1998.0341
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发表时间：
1998-05-01
期刊：
影响因子：
5.7
通讯作者：
Apkarian, AV
中科院分区：
文献类型：
--
作者：
Gelnar, PA;Krauss, BR;Apkarian, AV
8名右撇子成年人接受了他们大脑的功能性磁共振成像（fMRI），同时对右手上的单个指尖（数字1，2或5）施加振动刺激。在手指刺激过程中，利用多层回波平面成像技术来研究人类初级体感（SI）皮层、位于外侧裂（SII区）上岸的皮层区域、颞叶和后顶叶皮层的组织。进行t检验和聚类大小分析以产生皮质激活图，其在所研究的所有四个皮质区域中表现出显著的感兴趣区域（ROI）。SI和SII区的显著感兴趣区的频率远高于后顶叶区和后顶叶区。在初级躯体感觉皮层中观察到多个数字表示，对应于该皮层的四个解剖分区（区域3a，3b，1和2），这表明人类躯体感觉皮层的组织类似于其他灵长类动物的组织。总体而言，在个体受试者活动图中不存在简单的内侧到外侧的身体位置表示。然而，数字1和数字5皮质代表之间的空间距离是最大的SI和SII区域内的组。多个活动参数的统计分析表明，皮层区域之间的显着差异，并在digit，这表明，皮层的振动触觉激活是依赖于两个刺激的数字和皮层区域的调查。(C)北京：科学出版社.
Eight right-handed adult humans underwent functional magnetic resonance imaging (fMRI) of their brain while a vibratory stimulus was applied to an individual digit tip (digit 1, 2, or 5) on the right hand. Multislice echoplanar imaging techniques were utilized during digit stimulation to investigate the organization of the human primary somatosensory (SI) cortex, cortical regions located on the upper bank of the Sylvian fissure (SII region), insula, and posterior parietal cortices. The t test and cluster size analyses were performed to produce cortical activation maps, which exhibited significant regions of interest (ROIs) in all four cortical regions investigated. The frequency of significant ROIs was much higher in SI and the SII region than in the insula and posterior parietal region. Multiple digit representations were observed in the primary somatosensory cortex, corresponding to the four anatomic subdivisions of this cortex (areas 3a, 3b, 1, and 2), suggesting that the organization of the human somatosensory cortex resembles that described in other primates. Overall, there was no simple medial to lateral somatotopic representation in individual subject activity maps. However, the spatial distance between digit 1 and digit 5 cortical representations was the greatest in both SI and the SII region within the group. Statistical analyses of multiple activity parameters showed significant differences between cortical regions and between dig-its, indicating that vibrotactile activations of the cortex are dependent on both the stimulated digit and cortical region investigated. (C) 1998 Academic Press.