Targeting Cytokines as Evolving Treatment Strategies in Chronic Inflammatory Airway Diseases.
Targeting Cytokines as Evolving Treatment Strategies in Chronic Inflammatory Airway Diseases.
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DOI：
10.3390/ijms19113402
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发表时间：
2018-10-30
影响因子：
5.6
通讯作者：
Krick S
中科院分区：
文献类型：
--
作者：
Garth J;Barnes JW;Krick S
细胞因子是慢性炎症性气道疾病如慢性阻塞性肺病（COPD）、支气管扩张和过敏性哮喘中炎症起始和传播的关键因素。这使得它们成为特定的新型抗炎治疗策略的有吸引力的靶标。最近，白细胞介素-1（IL-1）和IL-6均与COPD的不良健康结局、死亡率和促炎表型相关。COPD患者的IL-6与肺功能呈负相关，而IL-1 β可被香烟烟雾诱导至支气管上皮，引起气道炎症。此外，IL-8已被证明是支气管扩张症、COPD和过敏性哮喘中的促炎标志物。目前正在进行使用特定细胞因子阻断疗法的临床试验，这些试验有助于减少COPD的急性加重和类固醇使用。在这里，我们提出了一个审查目前的理解细胞因子在慢性炎症性气道疾病的病理生理学的作用。此外，将讨论细胞因子阻断作为选定患者人群的新治疗策略的临床试验结果。
Cytokines are key players in the initiation and propagation of inflammation in chronic inflammatory airway diseases such as chronic obstructive pulmonary disease (COPD), bronchiectasis and allergic asthma. This makes them attractive targets for specific novel anti-inflammatory treatment strategies. Recently, both interleukin-1 (IL-1) and IL-6 have been associated with negative health outcomes, mortality and a pro-inflammatory phenotype in COPD. IL-6 in COPD was shown to correlate negatively with lung function, and IL-1beta was induced by cigarette smoke in the bronchial epithelium, causing airway inflammation. Furthermore, IL-8 has been shown to be a pro-inflammatory marker in bronchiectasis, COPD and allergic asthma. Clinical trials using specific cytokine blockade therapies are currently emerging and have contributed to reduce exacerbations and steroid use in COPD. Here, we present a review of the current understanding of the roles of cytokines in the pathophysiology of chronic inflammatory airway diseases. Furthermore, outcomes of clinical trials in cytokine blockade as novel treatment strategies for selected patient populations with those diseases will be discussed.
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DOI：
10.1073/pnas.0408535102
发表时间：
2005-01-11
影响因子：
11.1
作者：
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影响因子：
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DOI：
10.1513/pats.200807-069th
发表时间：
2008-12-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
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作者：
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通讯作者：
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影响因子：
3.1
作者：
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